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Research Institute

Research Department Introduction

Research Institute

Medical Research Institute

Research Department Introduction

FY2021 Research Department Organization Table

We transitioned to a new research department in April 2021.

Director of Medical Research Institute
  • TAKETO(Taketo) Makoto
Deputy Director, Medical Research Institute
  • FUKUI Motonari (Vice Director and Chief of the Department of Respiratory Medicine)
  • MUKAIHideyuki (Chief of Clinical Laboratory Department)
New research department name About the New Research Department Main department New Research Director
tumor The Oncology Division conducts research into malignant tumors of the digestive system, respiratory system, genitourinary system, female reproductive system, breast, and hematopoietic system. In clinical practice, we conduct research based on scientific evidence, not just guidelines, and we also engage in basic research using molecular biology and applied research in clinical settings, with the aim of further improving cancer treatment.
  • Gastrointestinal surgery
  • Gastroenterology
  • respiratory surgery
  • breast surgery
  • Urology
  • Obstetrics and Gynecology
  • Hematology
  • Medical Oncology
  • Pathology
  • Palliative Care
 HONJO Gen
(pathology)
Breathing/Circulation The Department of Respiratory and Circulatory Systems conducts research into diseases of the heart, blood vessels, and lungs, which are responsible for the respiratory and circulatory systems essential for maintaining life, as well as the physiological functions and disorders of the respiratory and circulatory systems.We also conduct research into medical devices necessary for maintaining life in the event of respiratory and circulatory disorders.
  • Cardiology
  • Cardiac Arrhythmia
  • Cardiovascular Surgery
  • Respiratory internal medicine
  • Department of Clinical Engineering
 HARUNA Tetsuya
(arrhythmia)
Endocrinology, metabolism, and kidneys The Department of Endocrinology, Metabolism and Nephrology conducts basic and clinical research aimed at elucidating the pathology of metabolic diseases such as diabetes and various endocrine diseases, as well as personalized medicine.In addition to clinical research utilizing kidney disease and kidney biopsy databases and basic research on glomerular diseases, we also conduct research on nutrition and dietary approaches to improve the pathology and treatment progress of various diseases.
  • Diabetic endocrinology
  • Nephrology
  • Nutrition Department
 HAMASAKI Akihiro
(in sugar)
Inflammation/immunity Inflammation is a biological response to injury, and is also triggered by the immune system, which is a mechanism that primarily eliminates pathogens and foreign substances. The Division of Inflammation and Immunology studies innate and adaptive immunity to self and non-self antigens, as well as their associated inflammatory responses, with the aim of elucidating the pathology of infectious diseases and immune disorders and establishing methods for their treatment and prevention.
  • Rheumatology and Collagen Diseases
  • dermatology
  • Infectious disease department
 IMURA Yoshitaka
(Rheumatism)
Nerves and sensory-motor organs The Department of Neurology and Sensorimotor Systems is researching pathologies that occur in the system that integrates and interprets information from the outside world, including visual, auditory, superficial, and proprioceptive senses, in the brain, and connects it to voluntary movement of muscles, bones, and joints via the central and peripheral nervous system. For example, after many years of research, regenerative therapy for the eardrum has been approved as a medical treatment covered by health insurance. We are also researching regenerative medicine for spinal cord injuries.
  • Neurology
  • ophthalmology
  • Neuropsychiatry
  • orthopedic surgery
  • plastic surgery
  • Neurosurgery
  • Otolaryngology/Head and Neck Surgery
 TODA Hiroki
(neuropathic)
Development and regeneration The Department of Development and Regeneration conducts clinical research in various specialized fields, such as immunology and allergy, hematology, neurology, metabolism and endocrinology, and neonates and premature infants in the fields of pediatrics and pediatric surgery. We publish case reports and clinical research results that lead to pathological elucidation and treatment, and at the same time, we work in cooperation with Kyoto University to focus on training research physicians.
  • Pediatrics
  • Pediatric Surgery
 SHIOTA Mitsutaka
(Children)
Pathophysiology and Pharmacology The Department of Pathophysiology and Pharmacology conducts research into the pathophysiology of the body's invasive response in acute severe illnesses such as surgery and sepsis in the Department of Anesthesiology, Intensive Care Unit, and Emergency Department, as well as the pharmacology that controls it. In addition, the Department of Pharmacy conducts clinical research aimed at improving the efficacy and safety of drug therapy.
  • Anesthesiology
  • intensive care department
  • Emergency Department
  • Pharmacy Department
 ONOUE Masahide
(drugs)
Health/health The Health and Wellness Department primarily conducts its own research on disease prevention and health promotion, as well as collaborative research with other research departments. Research is focused on tumors and the body's response to radiation, the safety of medical equipment and drugs, and lifestyle habits and disease prevention methods. In addition to the safety of testing and blood transfusions, the department also conducts research on medical information management and data mining, clinical research aimed at improving the quality of nursing, research aimed at improving physical function through rehabilitation, and research into the occurrence and prevention of oral diseases.
  • Radiology Department
  • Health Management Center
  • Clinical Laboratory Department
  • Medical Information Department
  • Nursing Department
  • Rehabilitation Department
  • Dentistry and Oral Surgery
 TERAI Mineko
(nursing)

Public research funding adoption and management status

As of August 2025 (Reiwa 7)

Grant-in-Aid for Scientific Research (Principal Investigator)

Event Research representative Research topic 　
Grant-in-Aid for Scientific Research (C) Yu Matsubara Functional analysis of tertiary lymph nodes in immune checkpoint inhibitor-associated renal impairment 　
Grant-in-Aid for Scientific Research (C) Akihiro Osumi Development of a novel pre-transplant therapy targeting extracellular neutrophil traps in donor lungs 　
Grant-in-Aid for Scientific Research (C) Aya Nakajima Development of a predictive model for preserving laryngeal function in radiation therapy for laryngeal and hypopharyngeal cancers. 　
Grant-in-Aid for Scientific Research (C) Yuki Miyabe Investigation of methods for detecting and correcting errors caused by vertebral flexion, extension, and rotation in radiation therapy. 　
Grant-in-Aid for Scientific Research (C) Nobuya Inagaki Elucidation of the mechanism by which GIP/GLP-1 receptor co-stimulation enhances blood glucose lowering and weight loss effects. 　
Grant-in-Aid for Scientific Research (C) Hiroki Toda Elucidation of the functional anatomy of the cerebellum, thalamus, and cortical circuits in patients with Parkinson's disease and essential tremor. 　
Grant-in-Aid for Scientific Research (C) Akifumi Horie Functional elucidation of the effect of immune tolerance changes in human peripheral blood mononuclear cells (PBMCs) on improving embryo implantation. 　
Grant-in-Aid for Scientific Research (C) Hiroyuki Harada Elucidating the pathogenesis of early-onset tongue cancer through multi-omics analysis. New
Grant-in-Aid for Scientific Research (C) Masaru Takahashi Tooth regeneration through molecular targeted therapy using USAG-1 as the target molecule. New
Grant-in-Aid for Scientific Research (C) Atsuko Sakakibara Development of a cervical cancer prognosis prediction model aimed at promoting cancer control and supporting patients' decision-making. New
Young Researchers Hisatsugu Maekawa Research on the plasticity of cancer stem cells using a cancer cell library derived from colorectal cancer patients. 　
Young Researchers Shibue Kōson Exploring the mechanism of glucagon secretion regulation mediated by IRS1-regulated autophagy in pancreatic α-cells. 　
Young Researchers Kento Yamamoto The impact of the FGFR gene on sensitivity to novel molecular targeted therapies in colorectal cancer and its clinical significance. 　
Young Researchers Junya Kawazoe Control of hepatic ischemia-reperfusion injury through histamine receptor signaling and its application to liver transplantation. 　
Support for starting research activities Takuya Ishimura Development of a machine learning-based model for predicting the duration of peritoneal dialysis continuation New

Grants-in-Aid for Scientific Research (shared)

Event Co-researcher Research topic  
Grant-in-Aid for Scientific Research (A) Akifumi Horie Development of a novel intracellular ice crystal formation measurement method and next-generation three-dimensional tissue cryopreservation. New
Grant-in-Aid for Scientific Research (C) Makoto Muto Analysis of metastatic mechanisms of colorectal cancer stem cell subtypes using mouse models and clinical materials.  
Grant-in-Aid for Scientific Research (C) Yasuaki Nakagawa Investigating the potential significance of TRPC3/C6 signaling as a biomarker in heart failure patients.  
Grant-in-Aid for Scientific Research (C) UEDA Shugo Development of novel molecular targeted therapies for colorectal cancer: FGFR3IIIc inhibitors  
Grant-in-Aid for Scientific Research (C) Yoshihisa Okuchi Development of novel molecular targeted therapies for colorectal cancer: FGFR3IIIc inhibitors  
Grant-in-Aid for Scientific Research (C) Akifumi Horie Development of an embryo culture system tailored to the pathogenesis of SLE, focusing on the metabolome of cumulus cells.  
Grant-in-Aid for Scientific Research (C) Akifumi Horie Optimization of human ovarian tissue freezing methods for cancer and reproductive medicine. New
Grant-in-Aid for Scientific Research (C) Akifumi Horie Establishment of a novel preimplantation genetic diagnostic method combining dynamic analysis of embryonic morphology and non-invasive preimplantation genetic testing for aneuploidy. New
Grant-in-Aid for Scientific Research (C) HONDA Noritsugu Establishment of evaluation methods for respiratory muscle mass and function as outcomes of respiratory muscle training. New
Grant-in-Aid for Scientific Research (B) Yasuaki Nakagawa Comprehensive elucidation of the myocardial epigenomic control circuit involved in the pathogenesis of heart failure and identification of therapeutic targets.  
Grant-in-Aid for Scientific Research (B) Junya Kawazoe Elucidating the mechanism of hepatic ischemia-reperfusion injury using a metabolic immunological approach with mouse fatty liver transplantation.  
Grant-in-Aid for Scientific Research (B) Shojiro Inano Superfunctionalization of biological proteins by introducing covalently bonded artificial amino acids New
Challenging research (emerging research) Shojiro Inano Elucidating the pathogenesis of neurodegenerative diseases and exploring treatment methods using the proteolytic system  

Grants-in-Aid for Scientific Research from the Ministry of Health, Labour and Welfare / Grants-in-Aid for the Promotion of Health, Labour and Welfare Administration (shared contribution)

Research topics Co-researcher Research topic name  
Regional Healthcare Infrastructure Development Promotion Research Project Mihoko Terai Research aimed at promoting the use of information on medical safety disseminated by the government and other entities in medical institutions. New
Intractable disease policy research project Tatsuo Tsukamoto Strategic coordinated research to promote research aimed at overcoming intractable diseases and improving medical care.  
Comprehensive Research Project for Cancer Control Promotion Akifumi Horie Research aimed at establishing a psychosocial support system and a safe long-term specimen storage system for pediatric and AYA generation cancer patients in cancer and reproductive medicine—with the goal of improving survivorship.  

Japan Agency for Medical Research and Development (AMED) (Representative)

business Research and Development Representative R&D Project
Drug Discovery Support Promotion Project / Comprehensive Drug Discovery Support Project Shojiro Inano Searching for efficient methods to remove proteins that cause neurodegenerative diseases

Japan Agency for Medical Research and Development (AMED) (Contributing)

business Research and development contributor R&D Project
Drug Discovery Venture Ecosystem Strengthening Project Takayoshi Ishimori Development of MRI imaging biomarkers and observational studies after Phase I trials

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