In order to verify the hypothesis that "a decline in the function of the lymphatic system, which is involved in the excretion of waste products from the brain, is involved in Alzheimer's disease and normal pressure hydrocephalus," the Department of Neurosurgery at our hospital evaluated age-related changes in the brain of patients with normal pressure hydrocephalus using MRI and identified a substance closely related to this (L-PGDS).^{Figure 1}.

Figure 1

Furthermore, together with collaborators, we confirmed that L-PGDS not only adsorbs amyloid beta, a waste product in the brain, but also interacts with tau protein, which is thought to be one of the causes of dementia. This was reported in the international journal "Frontiers in Aging Neuroscience" on April 4, 2024.^*.

• ^*Lipocalin-type prostaglandin D synthase: a glymphopathy marker in idiopathic hydrocephalus

Medical Research Institute Kitano Hospital has been conducting research and providing cutting-edge treatment for normal pressure hydrocephalus for over 25 years. Furthermore, Dr. Minami Nishida, the corresponding author of this study, is serving as a member of the organizing committee for the International Hydrocephalus Congress, which will be held in Nagoya this year. (Hydrocephalus 2024 MeetingOur hospital will continue to conduct research in the future, aiming to provide benefits to patients with hydrocephalus.