｛ALL　PREVIOUS　International KITANO Endo Seminar (IKES)}

1． H. Koshiyama 'Effect of pioglitazone on carotid arterial insima-media thicknessin subjcets with type 2 diabetes' Special Comments on Lecture by Prof R Law (Division of Endocrinology, Diabetes, and Hypertension, University of California-Los Angeles School of Medicine) 10/3/03 (Four Seasons Hotel, Tokyo)

2. H. Koshiyama 'Beyond Glucose Lowering Effect of Actos: Anthiatherogenic action' New TZD Conference 10/26/03 (Okura Hotel,Tokyo) with Drs H Ishida (Prof, Kyorin Univ), Y Terauchi (Tokyo Univ), E Inzucchi (Assoc Prof, Yale Univeristy)

3. KITANO NST Lecture
Laura Matarese , MS, RD, LD, FADA, CNSD (Director, Nutritional Intestinal Rehabilitaion, The Cleveland Clinic Foundation, Cleveland, OH, USA), 1/30/04

4. KITANO ENDO SEMINAR & ENDOCRINE ROUND by Professor Robert D Utiger (Harvard Medical School) ,　2/7/04(KITANO Hall)
* Opening Remarks by Dr Kiyoshi Takatsuki (ex President, Medical Research Institute Kitano Hospital)
《1》 “Diagnosis of Thyroid Diseases -subclinical hypothyroidism & subclnical hyperthyroidism” by Professor Robert D Utiger, Special Comments by Dr Toshihide Yamamoto (Yamamoto Clinic) & Dr Junta Takamastu (Takamatsu Clinic),
《2》 Endocrine CaseDiscussion
1). Adrenal Case presented by Dr Sato: Special Comments by Dr Issei Tanaka (President, Kei-Han-Na Hospital)
2). Thyroid Case presented by Dr Kato
3). Ovarian Case presented by Dr Koshiyama, Pathological findindings presented by Dr Kosho Takasu(Director, Department of Pathology, )
《3》 Free Discussion, The Differences of Medicine between US & Japan: Special Comments by Dr Jun Minamikawa (Minamikawa Clinic)Host:Dept Diabetes & Endocrinology, Tazuke Kofu-kai Foundation Medical Research Institute Kitano Hospital, Co-operation:Osaka City North Division Medical Association

5. H. Koshiyama 'Therapy of type 2 diabetes -Status in Japan-' DM Joint Conference 3/1/04 (Hankyu Int'nl Hotel, Osaka) with Prof E S Horton (Vice President, Joslin Diabetes Center, Prof Harvard Medical School)

6. THE 2nd INTERNATIONAL KITANO ENDO SEMINAR
Date : November 20th (Saturday), 2004
Time : 2:30pm-3:30 pm
Place : １ｓｔ Conference Room of the 5th floor, Medical Research Institute KITANO Hospital
Opening Remarks : Dr Yoshio Yamaoka (President of Medical Research Institute KITANO Hospital, Emeritus Professor, Kyoto University)
Speciall Lecture : Dr Armen H Tashjian Jr (Emeritus Professor, Harvard Medical School & Harvard School of Public Health)
“Osteoporosis: SERMs and Anabolics as Therapeutic Options” Chair H. Koshiyama
Cooperated by Osaka City Kita-ku Medical Association

7. the 3rd INTERNATIONAL KITANO ENDO SEMINAR on March 2, 2005 with Dr James H Anderson, Jr (Medical Director, Diabetes, Eli Lilly Co＆ Associate Professor of Medicine Division of Endocrinology and Metabolism Indiana University Medical School) as the special guest.
Date : March 2, 2005
Time :6pm-7pm
Place : The 7th Conference Room, 5F, Medical Institute KITANO Hospital, Osaka, Japan.
CHAIR: Yoshiyuki Hamamoto, MDPhD (Deputy Director, Center for Diabetes & Endocrinology, Medical Institute KITANO Hospital)
Special Lecture

8. The 4th INTERNATIONAL KITANO ENDO SEMINAR was performed on September 17, 2005 with Professor Gordon Williams Jr as the special guest and with Drs Yoshimasa Shishiba, Tetsuo Nishikawa, Issei Tanaka, Yasumasa Iwasaki and Yoshio Nakamura as the special commentators. There were participants over 100 people, and the very hot discussions were made both about clinical and basic aspects of ‘Aldosterone’.

9. CLINICAL HYPERTENISION UPDATE -what is the difference of ARBs in impaired glucose　tolerance? -
�@. Sachiko Honjo "Effect of telmisartan in glycemic control in type 2 diabetes associated with hypertension (Chair: H Koshiyama)
�A. SPECIAL LECTURE Professor Theodore W Kurtz（UCSF）"Antidiabetic Effects of ARBs: Are All Molecules the Same?" 2005. 10.12 (The Ritz-Carlton Hotel Osaka) (Chair: T Ogihara; Professor Osaka University)

10. The 5th INTERNATIONAL KITANO ENDO SEMINAR on March 23, 2006 with Prof Ogawa and Prof Theodore W Kurtz（UCSF）.

11. The 6th IKES was performed on 9/23/06 as Prof Waters from UCSF as a special guest, who kindly said that it was a good and unique meeting. The residents were brave enough to ask several questions! (10/2).(see poster）

12. The 7th IKES was performed on10/11/06 as Prof Schernthaner from Austria, the former President of EASD. Dr Yoshimitsu Yamasaki, who is a Hospital Professor of Osaka Univeristy kindly worked as a chair, giving a special comment. .(see poster）

13. The 8th IKES was performed on11/16/06 as Dr　Daniel　Thiebaud　 from　Australia. Dr Yamamoto (Chuo-ku), Dr Shoichi Fukarama (Wyeth, Boston) kindlyly joined this seminar, giving special comments. (see poster）

14. The　9ｔｈ　IKES　was　performed on 1/15/07 evening with Dr Erik Renstrom from Sweden as a special guest. The theme was 'Basic Aspects of Diabetes Mellitus' focusing on pancreatic regeneration and regulation of pancreactic secretion.
Drs　Susumu　Seino,　S　Fujimoto,　Y.　Hamamoto, all of whom were previously working in this Institute, kindly joined this seminar.
Dr Renstrom from Lund Univ gave an excellent lecture. The wine party was held with cooperation of Hotel New Otani Osaka. Dr　Yutaka　Seino and Dr Naoto Katagami (Osaka Univeristy) also kindly joined this seminar.　We would like to express many thanks to participants here. The 10th IKES has not been scheduled yet, but we hope that it will be a big one considering the 10th meeting next time!
　(see poster）

15. Round Table Discussion “Preventive Strategy against Coronary Artery Disease in Diabetes Mellitus”
　　　・ Dr Peter Gaeda (Glostrup Univeristy Hospital; Investigator of Steno2 Study)
　　　・ H. Koshiyama (Medical Research Institute KITANO Hospiral)
Professor Syunichi Miyazaki (Department of Circulatory Medicine, Kinki University Faculty of Medicine)　April 6th, 2007 (Hilton Osaka, Osaka)

16. The 10th th INTERNATIONAL KITANO ENDO SEMINAR (IKES) on June 25th(Monday), 2007 with Assistant Prof Yoshiyuki Hamamoto and Prof Theodore W Kurtz（UCSF）.

17. Round Table Discussion, "Therapeutic strategy against atherosclerosis in diabetes mellitus" Chair H. Koshiyama, K..Tobe (Professor, Toyama University) M.Hanefeld (Professor, Centre for Clinical Studies, GWT Technical University, Dresden, Germany), May24th,2007 (Sendai）

18. Round Table Discussion, Chair H. Koshiyama(Medical Research Institute KITANO Hospiral)
“Introduction of insulin with consideration of its efficay, safety and utility” Dr Pablo Mora (Associate Professor, Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Texas Southwestern Medical Center at Dallas, Saint Hiospital Dallas, USA)
Chairman: H. Koshiyama (Medical Research Institute KITANO Hospiral& Kyoto Univeristy)
Dr Hiroki Ikeda (Medical Research Institute KITANO Hospiral)
Dr Yoshiyuki Hamamoto (Medical Research Institute KITANO Hospiral and Kyoto Univeristy)
Dr Naoto Katakami(Osaka University)
Dr Tomomi Fujisawa (Osaka University)
The efficay, safety and usefulness of premixed insulin analog in treating diabetes mellitus was discussed, based on the presentation of Dr Pablo Mora about several clinical trials, such as INITIATE, PREFER and JDDM.
Photographs
April 18th, 2007(Hotel Granvia Osaka, Osaka)

19. Dr Jorge Plutzky from Harvard Medical School as a special guest of The 11th IKES (Int’l KITANO ENDO Seminar) on September 1st , 2007 (Saturday).

20. The 12th INTERNATIONAL KITANO ENDO SEMINAR (IKES) on May 10th,2008　with Professor Gordon Williams from Harvad Medical School as a special guest.

21. The 13th IKES on November　17th, with `Professor Vivian　Fonseca　from Tulane　Univeristy as a special guest.

22. The 14th IKES on April　17th, with Dr. Peter Vestergaard from The Osteoporosis Clinic Aarhus Amtssygehus (Denmark) as a special guest.

23. The 15th IKES on May　14th, with Professor John W Funder from Prince Henry's Institute of Medical Research as a special guest.

24. The 16th IKES on July　29th, with Alan Moses (Global Chief Medical Officer, Novo Nordisk Inc, USA) as a special guest.

25. The 17th IKES on February　5th, with Paola Fioretto (University of PadovaPadova Medical School) as a special guest.

26. The 18th IKES on March　27th, with Paul　M　Yen (Associate Professor Duke-NUS Graduate Medical School and Duke University School of Medicine Director, Laboratory of Hormonal Regulation Cardiovascular and Metabolic Diseases Program) as a special guest.

27. The 19th IKES on March　29th, with John Betterridge (Professor of Endocrinology and Metabolism University College Medical School, London UK Associate Dean Royal Society of Medicine London, UK) as a special guest.

28. INTERNATIONAL KITANO SEMINAR on May　6th, with Preston Mason (Harvard Medical School) as a special guest.

29. James E Foley, PhD, who gave us a talk about "Update of DPPIV inhibitors, especially of vildagliptin" on March 18, 2010.

30 . The 20th IKES on October 23th, with Steven Haffner (Professor of Internal Medicine, University of Texas Health Science Center) as a special guest.

31 . The INTERNATIONAL KITANO Nurse Diabetes & Endo SEMINAR (IKNDES) on October 23th, with Eri Matsumoto (Community Hospital of the Monterey Peninsula　FNP (Family Nurse Practitioner）) as a special guest.

32. Henning　Andersen, MD, visited us on January 27th, 2011. He　gave us a talk about the resuls of the on-going clincal trials with biphasic insulin analog, which our center is joining.

33 . The 21st IKES on March 3rd, with Susan Bonner-Weir (Professor, Section on Islet Transplantation and Cell Biology) and Gordon C. Weir (Professor, Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School) as a special guest.

34 . The 22nd IKES on May 13th, with John W Funder (Professor, Prince Henry’s Institute of Medical Research) as a special guest.

35 . The 23rd IKES on October 1st, with David Raymond OWENS, MD, PhD (Professor, Centre for Endocrine & Diabetes Sciences, Cardiff University, UK) as a special guest.

1. Koshiyama H, Kuwamura N, Nakamura Y, Minamikawa J, Tachibana M, Miyauchi A, Ishimura E, Imai Y, Jonsson JB, Juppner H. Analysis of expression and circulating level of FGF-23 in non-McCune Albright syndrome fibrous dysplasia. IBMS-JSBMR 2003, 2003.6.3?7 (Osaka).

2. Yamamoto T, Imanishi Y, Koshiyama H, Miyoshi Y, Shimizu N, Kinoshita E, Nakagomi Y, Miyauchi A, Satomura K, Inaba M, Sugimoto T, Nishizawasa Y, Juppner H, Ozono K. Increased circulating level of FGF-23 in patinets with McCune -Albright syndrome. American Society for Bone & Mineral Research, 2003.9.19-23. Minneapolis, MN, USA

3. Koshiyama H, Kuwamura N, Nakamura Y, Shimono D, Seino Y. The relationship of initma-media thickness of carotid artery to multiple risk factors in Japanese subjects with type 2 diabetes. XIIIth International Symposiumon Atherosclerosis. 2003.9.28-10.2（Kyoto）

4. Koshiyama H, Kuwamura N, Nakamura Y, Shimono D, Seino Y. The long-term effects of PPAR? agonist in subjects with type 2 diabetes. XIIIth International Symposium on Atherosclerosis. 2003.9.28-10.2（Kyoto）

5. Imanishi Y, Kobayashi K, Koshiyama H, Miyauchi A, Goto H, Yamamoto T, Ohashi H, Nakatsuka K, Inaba M, Ishimura E, Nishizawaa Y. The expression of FGF-23 in the fibrous dysplasia (FD) tissues with non-McCune Albright syndrome. 36th Annal Meeting of the Amerecan Society of Nephrology, 2003. 11.12-17 (San Diego, CA, USA).

6. Hamamoto Y, Akashi T, Inada A, Bonner-Weir S, Weir G. No evidence for contribution of recipient precursor cells for replenishment of β-cells in transplanted isletds(OP). The 65th ADA Scientific meeting, 2005.6.10-14 (San Diego, USA)

7. Koshiyama H, Honjo S, Wada Y, Nishi Y, HamamotoY.. Effect of telmisartan on glycemic control in Japanese diabetic patients with hypertension (PO). The 65th ADA Scientific meeting,.2005.6.10-14 (San Diego, USA)

8. Ikeda H, Nakamura Y, Minamikawa J, Koshiyama H. Comparison of effects of amlodipine and angiotensin receptor blockers on intima-media thickness of carotid artery in patients with type 2 diabetes mellitus(PO). The 66th ADA Scientific meeting. 2006.6.9-13(Washington DC, USA

9. Hamamoto Y, Honjo S, Ikeda H, Wada Y, Koshiyama H. Effects of short-term insulin therapy on type 2 diabetic patients(PO). The 66th ADA Scientific meeting. 2006.6.9-13(Washington DC, USA)

10. Koshiyama H, Ikeda H, Wada Y, Hamamoto Y, Honjo S. Effect of Telmisartan on Glycemic Control and Intima-Media Thickness in Subjects with Type 2 Diabetes. The Endocrie Society Meeting 2006.6.24-26 (Boston, USA)

11. Koshiyhama H, Honjo S, Nakamura Y, Tanaka K, Tsugawa N, OkanoT. Vitamin D Level in Japanese Aged Subjects with Type 2 Diabetes. The Endocrie Society Meeting 2006.6.24-26 (Boston, USA)

12. WadaY, Hamamoto Y, Hosokawa R,Honjo S, Ikeda H, Nabe, K Nomura K, Fujikawa J, Fukushima M, Ito K, Koshiyama H. Comparison of risk factors between the regular check-up in a company and the ‘human dock’ in Japanese male subjects.. Satellite Symposium of the EAS 76th Congress ‘Metabolic Syndrome’. 2007.6.8-9, 2007(Turku, Finland)

13. Ikeda, H, Nakamura Y, Minamikawa J, Honjo S, Hamamoto Y, Wada Y, Nabe K, Koshiyama H. Comparison of Effects of Amlodipine and Angiotensin Receptor Blockers on the Intima-media Thickness of Carotid Arterial Wall (AAA Study: Amlodipine vs ARB in Atherosclerosis Study). The European Atherosclerosis Society 76TH CONGRESS, 2007.6.10-13 (HELSINKI, FINLAND)

14. Wada Y, Fukushima M, HonjoS, Ikeda H, Nabe K, Nomura K, Hamamoto Y, Koshiyama H. Liver function may be associated with development of hypertension and diabetes mellitus in Japanese men. The European Atherosclerosis Society 76TH CONGRESS, 2007.6.10-13 (HELSINKI, FINLAND)

15. Hamamoto Y, Honjo S, Ikeda H, Nabe K, Nomura K, Wada Y, Koshiyama H. Suit index is a useful predictor of the beneficial effect of short-period insuolin therapy in type 2 diabeitc patients. The 43rd Annual Meeting of the European Association for the Study of Diabetes (EASD) 2007.9.17-21 (Amsterdam, the Holland)

16. Hamamoto Y, Honjo S, Ikeda H, Wada Y, Koshiyama H, Inagaki Y. The usefulness of SUIT index a to predict the effectiveness of short-period insuolin therapy on glyceamic control in type 2 diabeitc patients.　14th Japan-Korea Symposium on Diabetes Mellitus. 2007.10.5-6 (Kyoto, Japan).

17. Kimura T, Ikeda h, Nomura K, Aoyama T, Nabe K, Hamamoto Y, Honjo S, Fujikawa J, Koshiyama H. Usefulness of cystatin C in T2DM. 14th Japan-Korea Symposium on Diabetes Mellitus. 2007.10.5-6 (Kyoto, Japan).

18. Aoyama M, Ikeda H, Honjo S, Nabe K, Nomura K, Kimura T, Wada Y, Hamamoto Y, Hosokawa R, Koshiyama H. Clinical characteristcs of Japanaese patients with low titers of autoantiodies to GAD. 14th Japan-Korea Symposium on Diabetes Mellitus. 2007.10.5-6 (Kyoto, Japan).

19. Nabe K. Nomura K, Ikeda H, Honjo S, Wada Y, Kimura T, Aoyama T, Hamamoto Y, Koshiyama H. Association of diabetes mellitus in Japanese subjects, especially effect of atypical antipsychotic agents.. 7th International Diabetes Foundation Western Pacific Congress (IDF WPR) 2008.3.30-4.3 Wellington, New Zealand.

20. Nakayama K, Ikeda H, Honjo S, Nabe K, Nomura K, Kimura T, Aoyama T, Wada S, Koshiyama H. Recognition HbA1C among Japanese patients with diabetes and effect of education using brochure. 7th International Diabetes Foundation Western Pacific Congress (IDF WPR) 2008.3.30-4.3 Wellington, New Zealand.

21. Nomura K, Kikuchi O, Hamamoto Y, Honjo S, Ikeda H, Nave K, Wada Y, Koshiyama H. Relationship between carotid ultrasonography and silent cerebral infarction in Japanese subjects with type 2 diabetes. 7th International Diabetes Foundation Western Pacific Congress (IDF WPR) 2008.3.30-4.3 Wellington, New Zealand.

22. Koshiyama K, Fujioka Y, Taniguchi A, Tanaka K, Kagimoto S, Hirata K, Nakamura Y, Iwakura A, Hara K, Yamammoto T, Kuroe A, Ohya M, FujimotoS, Hamamoto Y, Honjo S, Ikeda H, Nabe K, TsudaK, Inagaki N, Seino Y, Kume N. Pitavastain improves lipid profiles and reduces high-sensitivity CRP(hs-CRP) in Japanese diabetic subjects with hypercholesterolemia (KISHIMEN multi-center prospetcive study)-subanalysis of diabetic subjects. The 7th International Diabetes Foundation Western Pacific Congress (IDF WPR) 2008.3.30-4.3 Wellington, New Zealand.

23. Aoyama T, Ikeda H, Honjo S, Nabe K, Nomura K, Kimura T, Hamamoto Y, Fujikawa J, Koshiyama H. GAD autoantibody level discriminates two subtypes of type 1 diabetes of Japanese adult patients.(PS) The 68th ADA Scientific meeting, 2008.6.6-10 (SanFrancisco, CA, USA)

24. Kimura T, Ikeda H, Fujikawa J, Nomura K, Aoyama T, Wada Y, Nabe K, Hamamoto Y, Honjo S, Koshiyama H. Usefulness of serum cystain C and parathyroid horumone as renal function markers in Japanese subjects with type 2 diabetes. (PS) The 68th ADA Scientific meeting, 2008.6.6-10 (SanFrancisco, CA, USA)

25. Koshiyama K, Fujioka Y, Taniguchi A, Tanaka K, Kagimoto S, Hirata K, Nakamura Y, Iwakura A, Hara K, Yamammoto T, Kuroe A, Ohya M, FujimotoS, Hamamoto Y, Honjo S, Ikeda H, Nabe K, TsudaK, Inagaki N, Seino Y, Kume N. Effects of pitavastatin on lipid profiles and high-sensitivity CRP and its safety in Japanese diabetic subjects with hypercholesterolemia: subanalysis of KISHIMEN Study (PO). The 68th ADA Scientific meeting, 2008.6.6-10 (SanFrancisco, CA, USA)

26. Hamamoto Y, Honjo S, Hamasaki A, Ikeda H, Wada Y, Koshiyama H, Inagaki N. Pretreatment factors predicting the beneficial effect of telmisartan on glycemic control in Japanese subjects with type 2 diabetes (PO). The 68th ADA Scientific meeting, 2008.6.6-10 (SanFrancisco, CA, USA)

27. Kume N, Fujioka Y, Taniguchi A, Tanaka K, Kagimoto S, Hirata K, Nakamura Y, Iwakura A, Hara K, Yamammoto T, Kuroe A, Ohya M, FujimotoS, Hamamoto Y, Honjo S, Ikeda H, Nabe K, Tsuda K, Inagaki N, Seino Y,, Koshiiyama H. Pitavastatin improves lipid profiles and reduces high-sensitivity CRP in Japanese subjects with hypercholesterolemia-KISHIMEN multi-center prospective study　European Society of Cardiology Congress 2008, 2008.9.1 (Munich, Germany)

28. Kimura T, Ikeda H, Fujikawa J, Nomura K, Aoyama T, Wada Y, Nabe K, Hamamoto Y, Honjo S, Koshiyama H. Usefulness of serum cystain C and parathyroid horumone as renal function markers in Japanese subjects with type 2 diabetes. The 44th Annual Meeting of the European Association for the Study of Diabetes (EASD) 2008.9.7-11 (Rome, Italy)

29. Wada Y, Hamamoto Y, Honjo S, Fujikawa J, Hosokawa R, Ikeda H, Nabe K, Kimura T, Aoyama T, Nomura K, LkoshiyamaH. The change of serum gamma-glutamyltransferase is associated with those of tryglycerides and blood pressure and with worsening of glucose tolerance in Japanese male subjects. The 44th Annual Meeting of the European Association for the Study of Diabetes (EASD) 2008.9.7-11 (Rome, Italy)

30. Aoyama T, Ikeda H, Honjo S, Nabe K, Nomura K, Kimura T, Hamamoto Y, Fujikawa J, Koshiyama H. Two subtypes of type 1 diabetes of Japaaese adult patients with low and high titers of GAD autoantibody. The 44th Annual Meeting of the European Association for the Study of Diabetes (EASD) 2008.9.7-11 (Rome, Italy)

31. Iwasaki Y, Honjo S, Hamamoto Y, Kawasaki Y, Ikeda H, Wada Y, Koshiyama H. A difficult case with primary aldosteronism.: #1 APA and cortisol-producing adenoma. The 2nd　International Aldosterone Forum in Japan. 2009.5.16 (Tokyo)

32. Inano S, Honjo S, Hamamoto Y, Kawasaki Y, Ikeda H, Wada Y, Koshiyama H. A difficult case with primary aldosteronism:#2 bilateral triple APAs and subcnlinial Cushing’s syndrome. The 2nd　International Aldosterone Forum in Japan 2009.5.16 (Tokyo)

33. Murakami I, Honjo S, Iwasaki Y, Hamamoto Y, Kawasaki Y, Ikeda H, Nomura K, Wada Y, Koshiyama H. A difficult case with primary aldosteronism: #3 primary aldosteronism and subclinical Cushing’s syndrome. The 2nd　International Aldosterone Forum in Japan. 2009.5.16 (Tokyo)

34. Iwasaki Y, Honjo S, Hamamoto Y, Kawasaki Y, Ikeda H, Wada Y, Koshiyama H. A difficult case with primary aldosteronism.: #1 APA and cortisol-producing adenoma. The 2nd　International Aldosterone Forum in Japan. 2009.5.16（Tokyo）

35. Inano S, Honjo S, Hamamoto Y, Kawasaki Y, Ikeda H, Wada Y, Koshiyama H. A difficult case with primary aldosteronism:#2 bilateral triple APAs and subcnlinial Cushing’s syndrome. The 2nd　International Aldosterone Forum in Japan 2009.5.16（Tokyo）

36. Murakami I, Honjo S, Iwasaki Y, Hamamoto Y, Kawasaki Y, Ikeda H, Nomura K, Wada Y, Koshiyama H. A difficult case with primary aldosteronism: #3 primary aldosteronism and subclinical Cushing’s syndrome. The 2nd　International Aldosterone Forum in Japan. 2009.5.16（Tokyo）

37. Wada Y, Yokoi T, Sanada F, Ikeuchi K, oshika M, Masuda M, Komiyama Y, Taniyama Y, Masaki H, Morishita R, Koshiyama H, Takahashi H. Ursodeoxycholic acid inhibits endothelial cell plasminogen activator inhibitor-1 expression induced by high glucose depend on transforming growth factor signaling. The 69th ADA Scientific meeting, 2009. 6.5-9 (New Orleans, LO, USA)

38. Kume N, Fujioka Y, Taniguchi A, Tanaka K, Kagimoto S, Hirata K, Nakamura Y, Iwakura A, Hara K, Yamammoto T, Kuroe A, Ohya M, FujimotoS, Hamamoto Y, Honjo S, Ikeda H, Nabe K, TsudaK, Inagaki N, Seino Y,, Koshiiyama H. Pitavastatin improves lipid profiles and reduces high-sensitivity CRP in Japanese subjects with hypercholesterolemia-KISHIMEN multi-center prospective study. The XV International Symposium on Atherosclerosis. 2009.6.14-18. (Boston, MA, USA)

39. S. Yamane1, Y. Hamamoto1, N. Harada1, K. Toyoda1, Y. Seino2, N. Inagaki. Evaluation of the effect of GLP-1 receptor activation on ER stress mediated beta cell damage in Akita miceThe 45th Annual Meeting of the European Association for the Study of Diabetes (EASD) 2009.9.29-10.2 (Wien, Australia)

40. Inano S, Honjo S, Iwasaki Y, Nomura K, Kawasaki Y, Hamamoto Y, Ikeda H, Koshiyama H, Sano H. Two cases of male gonadotropin cell adenoma. The 11th International Pitutiary Pathology Society (IPPS) Meeting, 200.9.10.16-20. (Awaji, Japan)

41. Iwasaki Y, Honjo S, Hamamoto Y, Ikeda H, Nomura K, Wada Y, Nohara R, Koshiyama H. Acute onset diabetic ketosis in Japanese patients: clinical course and prognosis. The 20th International Diabetes Congress 2009. 2009.10.18-10.22(Montreal, Canada)

42. Kawasaki K, Honjo S, Hamamoto Y, Ikeda H, Nomura K, Wada Y, Nohara R, Koshiyama H. Screening strategy for asymptomatic coronary heart disease in Japanese patients with diabetes mellitus. The 20th International Diabetes Foundation 2009.10.18-22(Montreal, Canada)

43. Nomura K, Hamamoto Y, Takahara S, Kikuchi O, Honjo S, Ikeda H, Wada Y, Kawasaki Y, Okumura R, Koshiyama H. Relationship between carotid intima-media thicknes and silent cerebral infarction in Japanese subjects with type 2 diabetes. The 20th International Diabetes Foundation 2009.10.18-22(Montreal, Canada)

44. Wada Y, Hamamoto Y, Nomura K, Honjo S, Fujikawa J, Ikeda H, Kawasaki Y, Iwasaki Y, Koshiyama H. The change in plasma calcium is associated with those in lipid and glucose tolerance in Japanese subjects with fatty liver. The 20th International Diabetes Foundation 2009.10.18-22(Montreal, Canada)

45. Koshiyama H, Ogawa Y, Tanaka K, Tanaka I,　 Proposal for integrated network systems and evolutionary developmental endocrinology (Ins-Eden) The 14th International Congress on Endocrinology. 2010.3.26-30

46. Koshiyama H, Nomura K, Takahara S, Kikuchi O, Hamamoto Y, Honjo S, Ikeda H, Wada Y, Kawasaki Y Usefulness of Carotid Intima-Media Thickness as a Screening Method of Silent Cerebral Infarction in Japanese Subjects with Type 2 Diabetes. WCPD 2010 -6th World Congress on Prevention of Diabetes and its Complications 2010.4.8-11 (Dresden, Germany)

47. Koshiyama H, Nomura K, Ikeda H, Honjo S, Kawasaki Y, Hamamoto Y. Cardiac autonomic dysfunction is related to sleep-disordered breathing in nonobese diabetic subjects. CODHy 2010.5.13-17 (Prague, Czech Republic)→Oral Presentation

48. Wada　Y, Hamamoto Y, Honjo S, Ikeda H, Kawasaki Y, Iwasaki, Y, Nomura, K Koshiyama H.　Clinical Effects of Various Angiotensin II Receptor Blockers in Japanese subjects with type 2 diabetes. CODHy 2010.5.13-17 (Prague, Czech Republic)→The Best AbstractAward

49. Kawasaki Y, Hamamoto Y, Honjo S, Ikeda H, Wada Y, Nomura K, Iwasaki Y, Koshiyama H. Asymptomatic coronary heart disease is rare in Japanese subjects with type 2 diabetes. The 70th ADA Scientific Meeting, 2010.6.25-29 (Orland, USA)

50. Wada Y, Iwasaki Y, Hamamoto Y, Fujikawa J, Honjo S, Kawasaki H, Ikeda H, Nomura K, Koshiyama H. Seasonal variations in albumin/creatinine ratio in Japanese subjects with type 2 diabetes and nephropathy. The 70th ADA Scientific Meeting, 2010.6.25-29 (Orland, USA)

51. Kawasaki Y, Iwasaki Y, Hamamoto Y, Honjo S, Ikeda H, Wada Y, Nomura K, Takahasi J, Koshiyama H. Serum IGF-1 concentration is correlated with insulin resistance in patients with acromegaly. The 7th International Congress of Neuroendocrinology 2010.7.11-15（Rouen, France）

52. Wada Y, Nakamura Y, Honjo S, Hamamoto Y, Kawasaki Y, Ikeda H, Shimatsu A, Koshiyama H. Lymphocytic panhypophysitis: its clinical features of Japanese cases. The 7th International Congress of Neuroendocrinology 2010.7.11-15（Rouen, France）

53. Hamamoto Y, Kawasaki Y, Honjo S, Ikeda H, Wada Y, Nomura K, Iwasaki Y, Koshiyama H. Asymptomatic coronary heart disease is rare in Japanese subjects with type 2 diabetes. The 46th EASD Annual Meeting 2010.9.20-24(Stockholm, Sweden)

54. Wada Y, Iwasaki Y, Hamamoto Y, Fujikawa J, Honjo S, Kawasaki H, Ikeda H, Nomura K, Koshiyama H. Seasonal variations in albumin/creatinine ratio in Japanese subjects with type 2 diabetes and nephropathy. The 46th EASD Annual Meeting 2010.9.20-24 (Stockholm, Sweden)

55. Hamamoto Y, Ikeda H, Honjo S, Kawasaki Y, Mori K, Wada Y, Koshiyama H. Deteriorative effect on glycemic control of fixed combination of hydrochlorothiazide and ARBs in Japaesen type 2 diabetic patients with hypertension. The 3rd International Conference on Fixed Combination 2010.11.18-20 (Brisbane, Australia.

56. Mori K, Iwasaki Y, Kawasaki Y, Iwasaki Y, Honjo S, Hamamoto Y, Ikeda H, Wada Y, Nomura K, Takahasi Y, Takahasi J, Koshiyama H. Serum IGF-1 concentration is correlated with insulin resistance in patients with acromegaly. International Symposium of IGF-1, GH and Ghlerin/GHS: Climbing the Scientific Growth Ladder 2011.3.4-6(Orland, US)

57. Tanaka M, Matsumura T, Fujikawa J, Nakamura H, Nohara R, Honjo S, Koshiyama H. Quality improvement of osteoporosis-related health screening and health check-up. European Congress on Osteoporosis & Osteoarthritis 2011.3.23-26.(Barcelona, Spain).

58. Kume N, Koshiyama H, KISHIMEN Investigators. Pitavastatin Reduces Elevated Soluble Lectin-Like Oxidized LDL receptor-1 Levels in Subjects with Hypercholesterolemia: Sub-Analysis of Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN). 60th Anuual Scientific Session, American Coillege of Cardiology, 2011.4.3-5 (New Orleans, USA)

59. Koshiyama H, Kawasaki Y, Honjo S, Hamamoto Y, Mori K, Iwasaki Y, Ikeda H, Wada Y, Nomura K. Acromegaly and pheochromocytoma as clinical models of effect of IGF-1 and caecholamine on insulin resistance. 4TH International Conference on Prediabetes and the Metabolic Syndrome. 2011. 4.6-9 (Madrid, Spain).

60. Hamamoto Y, Honjo S, Kawasaki Y, Mori K, Ikeda H, Wada Y, Koshiyama H. The relation of insulin use and cancer risk: A study in Japanese patients with diabetes. 4TH International Conference on Prediabetes and the Metabolic Syndrome. 2011. 4.6-9 (Madrid, Spain).

61. Kume N, Fujioka Y, Taniguchi A, Kagimoto S, Nakamura Y, Yamamoto T, Fujimoto S, Hamamoto Y, Hirata K-I, Koshiyama H. Pitavastatin reduces elevated soluble lectin-like oxizied LDL receptor-1 levels in subjects with hypercholesterolemia: Sub-analysis of KISHIMEN multi-center prospective study. 2011. 4.6-9 (Madrid, Spain).

62. Ishida Y, Honjo S, Hamamoto Y, Kawasaki Y, Wada Y, Kato K, Kanamaru H, Omura M, Sasano H, Koshiyama H. CO-exising idiopathic hyperaldosteronism and cortisol produgin adnoma diagnosed by superselective adrenal venous sampling. sThe 4th International Aldosterone Forum in Japan, 2011.5.14 (Royal Park Hotel, Tokyo).

63. Koshiyama H, Kawasaki Y, Iwasaki Y, Mori K, Honjo S, Hamamoto Y, Ikeda H, Nomura K, Wada Y, Takahasi Y, Takahasi J. Correlation of serum IGF-1 level with insulin resistance in patients with acromegaly. The 93rd Endocrine Society Meeting 2011.6.4-7 (Boston, US)

64. Kawasaki Y, Hamamoto Y, Honjo S, Ikeda H, Wada Y, Nomura K, Iwasaki Y, Koshiyama H. Screening method for asymptomatic coronary heart disease in Japanese subjects with type 2 diabetes. The 71st ADA Scientific Meeting, 2011. 6.24.28 (SanDiego, US)

65. Hamamoto Y, Honjo S, Kawasaki Y, Mori K, Ikeda H, Wada Y, Koshiyama H. The relation of insulin use and cancer risk: A study in Japanese patients with diabetes (PO). The 71st ADA Scientific Meeting, 2011.6.24.28 (SanDiego, US)

65. Honjo S, Kawasaki Y, Hamamoto Y, Mori K, Ikeda H, Wada Y, Nomura K, Koshiyama H. Incidence and type of cancer in Japanese subjects with type 2 diabetes(PO). Th he 71st ADA Scientific Meeting, 2011.6.24.28 (SanDiego, US)

66. Nomura K, Ikeda H, Hamamoto Y, Honjo S, Kawasaki Y, Wada Y, Mori K, Koshiyama H. Cardiac Autonomic Neuropathy Is Related to Sleep-Disordered Breathing in Nonobese Japanese Subjects with Type 2 Diabetes(PO). Th he 71st ADA Scientific Meeting, 2011.6.24.28 (SanDiego, US)

67. Mori K, Hamamoto Y, Honjo S, Kawasaki Y, Tatuoka H, Fujimoto K, Ikeda H, Nomura K, Wada Y, Koshiyama H. Better glycaemic control with liraglutide than with exenatide in patients with diabetes associated with liver cirrhosis. The 3rd Annunal Meeting of The Asian Association for the Study of Diabetes (AASD) (Beijing, China) 2011.7.23

68. Shiba M, Fujimoto K, Hamamoto Y, Honjo S, Kawasaki Y, Mori K, Tatsuoka H, Ikeda H, Wada, Y, Kanemaru H, Fujikawa J, Koshiyama H. Does pioglitazone increase bladder cancer risk in Japanese? : Retrospective analysis in one institute. The 3rd Annunal Meeting of The Asian Association for the Study of Diabetes (AASD) (Beijing, China) 2011.7.23

69. Wada, Y, Hamamoto Y, Kawasaki Y, Honjo S, Mori K, Fujimoto K, Tatsuoka H, Ikeda H, Koshiyama H. Decreased development of intima-media thickness in subjects with type 2 diabetes and past history of gastrectomy. The 3rd Annunal Meeting of The Asian Association for the Study of Diabetes (AASD) (Beijing, China) 2011.7.23

70. Kawasaki Y, Hamamoto Y, Honjo S, Ikeda H, Wada Y, Nomura K, Iwasaki Y, Koshiyama H. Screening strategy for asymptomatic coronary heart disease in Japanese subjects with type 2 diabetes. The 47th EASD Annual Meeting 2011.9.12-16 (Lisbona, Portugal)

71. Nomura K, Ikeda H, Honjo S, Kawasaki Y, Hamamoto Y, Koshiyama H. The relationship between sleep-disordered breathing and cardiac autonomic dysfunction in nonobese diabetic subjects. The 47th EASD Annual Meeting 2011.9.12-16 (Lisbona, Portugal)

72. Honjo S, Kawasaki Y, Hamamoto Y, Mori K, Ikeda H, Wada Y, Nomura K, Koshiyama H. Incidence and type of cancer in Japanese subjects with type 2 diabetes. The 47th EASD Annual Meeting 2011.9.12-16 (Lisbona, Portugal)

73. Nakayama N et al. The activity of recently developed nurse practitioner in Japan-evaluation based on practical training in our intitute-. World Diabetes Congress Dubai 2011, International Diabetes Federation 2011.12.4-8 (Dubai, UAE).

74. Koshiyama H, Imaoka T, Onishi Y, Haber H, Boardman M. Safety and Efficacy of Exenatide Once Weekly Injection for 52 Weeks on Glucose Control in Japanese Patients with Type 2 Diabetes (late breaking). World Diabetes Congress Dubai 2011, International Diabetes Federation 2011.12.4-8 (Dubai, UAE).

75. Wada Y et al. Decreased development of intima-media thickness in subjects with type 2 diabetes and past history of gastrectomy (oral presentation). World Diabetes Congress Dubai 2011, International Diabetes Federation 2011.12.4-8 (Dubai, UAE).

1. Koshiyama H, Kato Y, Inoue T, Murakami Y, Ishikawa Y, Yanaihara N, Imura H. Central galanin stimulates pituitary prolactin secretion in rats: possible involvement of hypothalamic vasoactive intestinal polypeptide. Neurosci Lett 1987; 75:49-5

2. Koshiyama H, Kato Y, Ishikawa Y, Murakami Y, Inoue T, Imura H. Stimulation of prolactin secretion by L-3,4-dihydroxyphenylserine (L-DOPS) via central norepinephrine in the rat. Life Sci 1987;41:983-988.

3. Koshiyama H, Kato Y, Inoue T, Christophe J, Yanaihara N, Imura H.Helodermin stimulates prolactin secretion in the rat. Eur J Pharmac 1987;141:319-321.

4. Ishikawa Y, Kato Y, Murakami Y, Inoue T, Koshiyama H, Imura H. Effect of l-threo-3,4-dihydroxyphenylserine (L-DOPS) on catecholamine level in plasma and cerebrospinal fluid (CSF) in anesthetized rats. Proc Soc Exp Biol Med 1987;184:197-200.

5. Murakami Y, Kato Y, Kabayama Y, Inoue T, Koshiyama H, Imura H. Involvement of hypothalamic growth hormone (GH)-releasing factor in GH secretion induced by intracerebroventricular injection of somatostatin in rats. Endocrinology 1987;120:311-316.

6. Murakami Y, Kato Y, Koshiyama H, Inoue T, Ishikawa Y, Imura H.Involvement of alpha-adrenergic and GABAergic mechanisms in growth hormone secretion induced by central somatostatin in rats. Brain Res1987;407:405-408.

7. Murakami Y, Kato Y, Koshiyama H, Inoue T, Yanaihara N, Imura H. Galanin stimulates growth hormone (GH) secretion via GH-releasing factor (GRF) in conscious rats. Eur J Pharmac 1987;136:415-418.

8. Inoue T, Kato Y, Koshiyama H, Yanaihara N, Imura H. Galanin stimulates the release of vasoactive intestinal polypeptide from perifused hypothalamic fragments in vitro and from periventricular structures into the cerebrospinal fluid in vivo in the rat. Neurosci Lett 1988;85:95-100.

9. Inoue T, Kato Y, Koshiyama H, Yanaihra N, Imura H. Interaction between vasoactive intestinal polypeptide (VIP) in peptide histidine isoleucine (PHI) in stimulating the secretion of prolactin from rat anterior pituitary cell in vitro. Neurosci Lett 1988;85:363-369.

10. Murakami Y, Kato Y, Shimatsu A, Koshiyama H, Inoue T, Ishikawa Y, Hattori N, Imura H. Role of galanin and related peptides in prolactin and GH secretion in the rat. In : Imura H (ed) Neuroendocrine Control of the Hypothalamo-pituitary System. Karger, Tokyo, 1988; p 86-92.

11. Koshiyama H, Kato Y, Shimatsu A, Inoue T, Murakami Y, Ishikawa Y, Hattori N, Imura H. Effect of adrenalectomy on prolactin secretion induced by serotoninergic stimulation in the rat. In: Hoshino K (ed) Prolactin Gne Family and Its Receptors. Elsevier Science Publishers B.V.,Amsterdam. 1988; p 247-250.

12. Kato Y, Murakami Y, Koshiyama H, Hattori N, Imura H. Proalctinoma treatment with long-acting bromocriptine. In: Landalt M et al (ed) Advances in Pituitary Adenoma Research. Pergamon Press, New York, 1988;p 317-320.

13. Koshiyama H, Kato Y, Inoue T, Imura H. Involvement of hypothalamic vasoactive intestinal polypeptide in pituitary prolactin secretion induced by central galanin in rats. In: Hoshino K (ed) Kyoto Prolactin Conference Monograph, Shinko Printing Co, Kyoto , vol 3, 1988;p 1-10.

14. Koshiyama H, Kato Y, Shimatsu A, Imura H. The role of alpha-adrenergic system in the regulation of rat prolactin secretion. In: Hoshino K (ed) KyotoProlactin Conference Monograph, Shinko Printing Co, Kyoto Vol 4, 1989, p 68-77.

15. Koshiyama H, Kato Y, Shimatsu A, Imura H. Effects of clonidine and naloxone on the dopamine levels in the rat mediobasal hypothalamus measured by in vivo voltammetry. Neurosci Lett 1989;99:328-332.

16. Murakami Y, Kato Y, Shimatsu A, Koshiyama H, Hattori N, Yanaihara N, Imura H. Possible mechanisms involved in growth hormone secretion induced by galanin in the rat. Endocrinology 1989;122:1224-1229.

17. Koshiyama H, Kato Y, Shimatsu A, Murakami Y, Hattori N, Ishikawa Y, Imura H. Possible involvement of endogenous opioid peptides in prolactin ecretion induced by alpha2-adrenergic stimulation in rats. Proc Soc Exp Biol Med 1989;192:105-108.

18. Koshiyama H, Kato Y, Masutani H, Hashimoto N, Imura H. A case of Rathke's cleft cyst associated with diabetes insipidus and Hashimoto's thyroiditis. Jpn J Med 1989;28:406-409.

19. Hattori N, Shimatsu A, Kato Y, Koshiyama H, Ishikawa Y, Tanoh T, Assadian H, Imura H. Urinary excretion of human growth hormone; daily variation and relationship with albumin and alpha1-microglobulin in urine. Acta Endocrinol 1989;21:533-537.

20. Koshiyama H, Kato Y, Shimatsu A, Assadian H, Hattori N, Ishikawa Y, Tanoh T, Yanaihara N, Imura H. Galanin-induced prolactin release in rats; pharmacological evidence for the involvement of alpha-adrenergic and opioidergic mechanisms. Brain Res 1990;507:321-324.

21. Koshiyama H, Shimatsu A, Assadian H, Hattori N, Ishikawa Y, Tanoh T, Yanaihara N, Imura H. Galanin interacts with serotonin in stimulating prolactin secretion in rats. J Neuroendocrinol 1990; 2:217-220.

22. Hattori N, Shimatsu A, Kato Y, Koshiyama H, Ishikawa Y, Assadian H, Tanoh T, Nagasawa M, Imura H. Growth hormone response to oral loading measured by highly sensitive enzyme immunoassay in normal subjects and patients with glucose intolerance and acromegaly. J Clin Endocrinol Metab 1990; 70:771-776.

23. Assadian H, Shimatsu A, Tanoh T, Koshiyama H, Hattori N, Ishikawa Y, Tanoh T, Imura H. Secretion of alpha and TSH-beta subunits in patients with acromegaly: an in vivo study. Acta Endocrinol (Copenh). 1990;122: 729-734.

24. Hattori N, Shimatsu A, Tanoh T, Koshiyama H, Kato Y, Imura H. Evaluation of activity of postoperative acromegalics --- plasma growth hormone levels during oral glucose tolerance test, daily blood sampling and urinary on GH secretion. Endocrinol Jpn 1990; 37:629-637.

25. Koshiyama H, Tashjian AH Jr. Control of intracellular calcium redistribution by guanine nucleotides and inositol 1,4,5-trisphosphate in permeabilized GH4C1 cells. Endocrinology 1991; 128:2715-2722.

26. Koshiyama H, Tashjian AH Jr. Evidence for multiple intracellular calcium pools in GH4 C1 cells: investigations using thapsigargin. Biochem Biophys Res Commun 1991; 177:551-558.

27. Koshiyama H, Lee HC, Tashjian AH Jr. Novel mechanism of intracellular calcium release in pituitary cells. J Biol Chem 1991; 266:16985-16988.

28. Shimatsu A, Tanoh T, Koshiyama H, Murakami Y, Kato Y, Yanaihara N, Imura H. Role of galanin in prolactin and growth hormone secretion in rats.In: Hokfelt T, Bartafai T, Jacobowitz D, Ottosen D (eds) Galanin-a new multifunctional peptide in the neuro-endocrine system, MacMillan Press (London) 1991;p 321-329.

29. Tashjian AH Jr., Zhao D, Yang J, Jones KE, Gerald C, Hogan P, Chin WW, Koshiyama H, Tanaka Y. Intracellular calcium mobilization: molecular cloning of the rat lactotroph thyrotropin-releasing hormone receptor and the actions of cyclic ADP-ribose in mammalian cells. In: Calcium Regulating Hormones and Bone Metabolism; Basic and Clinical Aspects, vol 11, D.V. Cohn, C Gennari and AH Tashjian Jr. (eds), Elsevier Science Publishers B.V., Amsterdam, 1992, p 102-104.

30. Koshiyama H, Sakamoto M, Fujiwara K, Kim Y-C, Teraura T, Koh T. Chondroid chordoma presenting with hypopituitarism. Internal Medicine 1992,31(12)1366-1369.

31. Koshiyama H, Ohgaki K, Hida S, Takasu T, Yumitori K, Shimatsu A, Koh T. Metastatic renal cell carcinoma to the pituitary gland presenting with hypopituitarism. J Endocrinol Invest 1992; 15:677-681.

32. Koshiyama H, Mori S, Fujiwara K, Hayakawa K, Koh T. Successful treatment of hypothyroid Graves' disease with a combination of levothyroxine replacement, intravenous high-dose steroid and irradiation to the orbit. Internal Medicine 1993;32(5);421-423.

33. Koshiyama H, Sato H, Yorita S, Koh T, Kanatsuna T, Nishimura K, Hayakawa K, Takahashi J, Hashimoto N. Lymphocytic hypophysitis presenting with diabetes insipidus: case report and literature review. Endocrine J 1994;41(1);93-97.

34. Koshiyama H, Ito M, Yoshinami N, Masaki M, Yorita S, Tanaka M, Mizunoya S, Koh T. Two cases with asymptomatic adrenocortical insufficiency with autoimmune thyroid disease. Endocrine J 1994;41(4):373-378.

35. Koshiyama H, Koh T, Sone T. Therapeutic dilemma with thyroxine replacement in hypothyroidism (letter). Arch Intern Med1994; 155:1997

36. Koshiyama H, Koh T, Fujiwara K, Hayakawa K, Shimbo S-I, Misaki T. Therapy of Graves' ophthalmopathy with intravenous high-dose steroid followed by orbital irradiation. Thyroid 1994;4(4):409-413.

37. Tanaka M, Kim Y-C, Takasu K, Koh T, Koshiyama H. Three cases of primary hyperparathyroidism associated with nonmedullary thyroid carcinoma. Internal Medicine 1995;34(5):396-400.

38. Koshiyama H, Sone T, Nakao K. Vitamin-D-receptor-gene polymorphism and bone loss (letter). Lancet 1995;345(8955):990-991.

39. Shibutani Y, Inoue D, Koshiyama H, Mori T. Thyroid hemiagenesis with subacute thyroiditis. Thyroid 1995;5(2):133-135.

40. Takeuchi Y, Fukunaga Y, Inoue D, Sakaguchi H, Usami K, Fukata J, Koshiyama H. Severe Alpha-2 agonist withdrawal syndrome in diabetes mellitus (letter). Internal Medicine 1996;35(4):345.

41. Sakaguchi H, Inoue D, Kataoka K, Koshiyama H, Aoki N, Nakao K. Two cases of empty sella syndrome with variable dexamethasone-suppressibility of cortisol and ACTH. Endocrine Journal 1996; 43(4):417-422.

42. Koshiyama H, Sellitti DF, Akamizu T, Doi SQ, Takeuchi Y, Inoue D, Sakaguchi H, Takemura G, Sato Y, Takatsu Y, Nakao K. Cardiomyopathy associated with Graves' disease. Clin Endocrinol 1996; 45:11-116

43. Koshiyama H, Mori S, Koh T, Tatsuoka Y, Mune T, Katakami H. Familial idiopathic hypoparathyroidism: case report with PTHrP examination. Endocrine Journal 1996;43(5): 569-572.

44. Koshiyama H. The potential for serious consequences from misinterpretation of normal responses to the rapid adrenocorticotropin test (letter). J Clin Endocrinol Metab 1996; 81(11):4176.

45. Fukunaga Y, Inoue D, Koshiyama H. Localization of insulinomas by selective intraarterial calcium injection (letter). J Clin Endocrinol Metab 1996; 81(12):4501.

46. Yamamoto T, Yoshimasa Y, Koshiyama H, Sugiyama K, Okigaki M, Yamada T, Ishii H, Yagura T, Fujimoto K, Ohnishi T, Koh T, Hino M, Kurahachi H, Yoshimasa T, Nakao K. Lack of mutations of preproparathyroid hormone gene in three kindreds with familial hypoparathyroidism. Endocrine Journal 1997; 44(1),175-180.

47. Yanagita M, Inoue D, Akamizu T, Koshiyama H. Familial clustering of thyroid stimulation- blocking antibody (letter). Arch Intern Med 1997; 157:462-464.

48. Sakaguchi H, Maeda S, Fukunaga Y, Inoue D, Koshiyama H. Hypoglycemia associated with the administration of angiotensin-converting enzyme inhibitor in a patient of diabetes mellitus (letter). Internal Medicine 1997; 36(1):77.

49. Sakaguchi H, Koshiyama H, Sano T, Hashimoto N, Aoki N, Nakao K. A case of nonfunctioning pituitary adenoma resembling so-called silent corticotroph adenoma. Endocrine Journal 1997; 44(2):329-333.

50. Aizawa M, Koshiyama H, Inoue D, Fukunaga Y, Karakami H, Miki M, Mizuno M. Postoperative aggravation of hypercalcemia-leukocytosis syndrome in a case of suqamous cell type carcinoma (letter). Internal Medicine 1997;36(3):232.

51. Aizawa M, Sakaguchi H, Fukunaga Y, Ashida C, Koshiyama H. A case of non-insulin dependent diabetes mellitus associated with anorexia nervosa (letter). Internal Medicine 1997; 36(5):380.

52. Sellitti DF, Hill R, Doi SQ, Akamizu T, Czaja J, Goldstein R, Tao S, Koshiyama H. Differential expression of thyrotropin receptor mRNA in the porcine heart. Thyroid 1997; 7(4):641-646.

53. Sato H, Inoue D, Koshiyama H, Takahashi H, Kakudo K. Interest of routine measurement of serum calcitonin: study of thyroidectomized patients (letter). J Clin Endocrinol Metab 1997; 82(8):2755.

54. Fukunaga Y, Minamikawa J, Inoue D, Koshiyama H, Fujisawa I. Pseudoacromegaly and hyperinsulinemia: a possibility of premature atherosclerosis? (letter). J Clin Endocrinol Metab1997; 82(10):3515-3516.

55. Fukunaga Y, Azuma N, Koshiyama H, Inoue D, Sato H, Yoshimasa Y, Nakao K. Mitochondrial DNA 3243 mutation is infrequent in Japanese diabetic patients with auditory disturbance (letter). Diabetes Care 1997; 20(11):1800-1801.

56. Fukunaga Y, Minamikawa J, Inoue D, Koshiyama H. Does insulin use increase bone mineral density in non-insulin-dependent diabetes mellitus? (letter) Arch Intern Med 1997; 157:2668-2669.

57. Yamauchi M, Inoue D, Fukunaga Y, Kakudo K, Koshiyama H. A case of sarcoid reaction associated with papillary thyroid carcinoma. Thyroid 1997; 7(6):901-903.

58. Kakudo K, Shan L, Nakamura Y, Inoue D, Koshiyama H, Sato H. Clonal analysis helps to differentiate aberrant thyroid tissue from thyroid carcinoma. Human Pathology 1998; 29:187-190.

59. Minamikawa J, Yamauchi M, Tanaka S, Koshiyama H. Carotid arterial intimal-medial thickening and plaque formation in NIDDM (letter). Diabetes Care 1998; 21(2):323-324.

60. Minamikawa J, Yamauchi M, Inoue D, Koshiyama H. Another potential use of troglitazone in noninsulin dependent diabetes mellitus (letter). J Clin Endocrinol Metab 1998; 83(3):1041.

61. Minamikawa J, Tanaka S, Yamauchi M, Inoue D, Koshiyama H. Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes. J Clin Endocrinol Metab1998; 83(5):1818-1820.

62. Yamauchi M, Tadano M, Fukunaga Y, Inoue D, Minamikawa J, Koshiyama H. Low bone mineral density in a case of mosaicism Klinefelter syndrome: rapid response to testosterone therapy. Endocrine Journal 1998:45(4):601-604.

63. Juppner H, Schipani E, Bastepe M, Cole DEC, Lawson ML, Mannstadt M, Hendy GN, Plotkin H, Koshiyama H, Koh T, Crawford JD, Olsen BR, Vikkula M. The gene responsible for pseudohypoparathyroidism Ib is paternally imprinted and maps in four unrelated kindreds to chromosome 20q13.3. Proc Natl Acad Sci USA 1998;95:11798-11803.

64. Taniguchi R, Koshiyama H, Yamauchi M, Tanaka S, Inoue D, Muramatsu Y, Sasano H. A case of aldosterone-producing adenoma with severe postoperative hyperkalemia. Tohoku J Exp Med 1998; 146:215-223.

65. Sellitti DF, Dennison D, Akamizu T, Koshiyama H. Thyrotropin receptor (TSHR) in cultured human coronary artery smooth muscle cells. Am J Hyperrtens 11(4 suppl):144A, 1998.

66. Koshiyama H, Tanaka K, Nakao K. Is bone mineral density paradoxically increased in diabetic nephropathy? (letter) Arch Intern Med 1999;159:1145.

67. Koshiyama H, Tanaka S, Minamikawa J. Effect of calcium channel blocker amlodipine on intimal-medial thickness of carotid artery in type 2 diabetes. J Cardiovasc Pharm 1999;33:894-896.

68. Osafune K, Ichikawa K, Yasui T, Sekikawa A, Takeoka H, Kanatsu K, Kohigashi K, Koshiyama H. An adult-onset case of arginosuccinate synthetase deficiency presenting with atypical citrullinemia. Internal Medicine 1999; 38:590-596.

69. Koshiyama H, Doi SQ, Sellitti DF, Akamizu T, Nakao K. Comment on thyrotropin receptor mutation and mitral valve prolapse (letter) . J Clin Endocrinol Metab 1999; 84:3404-3405.

70. Yamauchi M, Inoue D, Sato H, Ashida C, Hiraumi H, Shan L, Kakudo K, Koshiyama H. A case of lateral aberrant thyroid associated with Graves' disease. Endocrine Journal 1999;46(5):731-734.

71. Shimono T, Yamaoka T, Nishimura K, Koshiyama H, Sakamoto M, Koh T, Hayakawa K. Lymphocytic hypophysitis presenting with diabetes insipidus: MR findings. Eur Raidol 1999; 23(9):1397-1400

72. Sellitti DF, Dennison D, Akamizu T, Doi SQ, Kohn LD, Koshiyama H. Thyrotropin in regulation of cyclic adenosine monophosphate (cAMP) production in human coronary arterial smooth muscle cells. Thyroid 2000; 10(3):219-225.

73. Koshiyama H, Tanaka S, Minamikawa J, Nakao K. Relationship between postprandial triglyceride level and intima-media thickness of carotid artery after troglitazone treatment in type 2 diabetes. In: Kita T, Yokode M (eds), Lipoprotein Metabolism and Atherogenesis, Springer , Tokyo 2000, p. 154-156.

74. Sellitti DF, Akamizu T, Doi SQ, Kopchik JJ, Koshiyama H. Renal expression of two ‘thyroid specific genes’, thyrotropin receptor and thyrogloblulin, in the kidney. Experimental Nephrology 2000;8(4-5):235-243.

75. Koshiyama H, Shimono D, Wada Y, Nakamura Y. Improvement of glycemic control after treatment with mosapride for diabetic gastropathy (letter). Diabetes Care 2000;23(8):1198-1199.

76. Koshiyama H, Nakamura Y, Tanaka S, Minamikawa J. Decrease in carotid intima-media thickness after one-year therapy with etidronate for osteopenia associated with type 2 diabetes. J Clin Endocrinol Metab 2000; 85(8):2793-2796.

77. Wada Y, Nakamura Y, Koshiyama H. Lack of positive correlation between statin use and bone mineral density in Japanese subjects with type 2 diabetes (letter). Arch Intern Med 2000; 160:2865.

78. Osafune K, Takeoka H, Kanamori H, Koshiyama H, Hirose K, Hadana M, Mimura R, Ando F, Kanatsu K. Crescentic glomerulonephritis associated with infective endocarditis: renal recovery after immediate surgical intervention. Clin Exp Nephrol 2000; 4:329-334.

79. Nakamura Y, Okada H, Wada Y, Kajiyama K, Koshiyama H. Lymphocytic hypophysitis: its expanding features. J Endocrinol Invest 2001; 24:262-267.

80. Bastepe M, Pincus JE, Sugimoto T, Tojo K, Kanatani M, Azuma Y, Kruse K, Rosenbloom AL, Koshiyama H, Juppner H. Positional dissociation between the genetic mutation responsible for pseudohypoparathyroidism type Ib anqqd the associated methylation defect at exon A/B: evidence for a long-range regulatory element within the imprinted GNAS 1 locus. Hum Mol Genet 2001; 10:1231-1241.

81. Shimono D, Kuwamura N, Nakamura Y, Koshiyama H. Lack of effect of pioglitazone on postprandial triglyceride level in type 2 diabetes (letter) Diabetes Care 2001; 24:971.

82. Koshiyama H, Shimono D, Kuwamura N, Minamikawa J, Nakamura Y. Inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes. J Clin Endocrinol Metab 2001; 86:3452-3456.

83. Nakamura Y, Son Y, Kohno Y, Shimono D, Kuwamura N, Koshiyama H, Sasano H, Matsuda T. A case of Adrenocorticotropic hormone-independent macronodular adrenal hyperplasia with possible adrenal hypersensitivity to angiotensin II. Endocrine 2001; 15:57-61.

84. Koshiyama H, Wada Y, Nakamura Y. Hypercholesterolemia as a possible risk factor for osteopenia in type 2 diabetes (letter). Arch Intern Med 2001; 161:1678.

85. Sellitti D, Doi Q, Akamizu T, Koshiyama H. Comment on thyrotropin receptor expression in cardiac muscle tissue. J Clin Endocrinol Metab 2002; 87(2): 946.

86. Nakamura Y, Doi R, Kohno Y, Shimono D, Kuwamura N, Ioue K, Koshiyama H, Imamura M. High-dose calcium stimulation test in a case of insulinoma masquerading as hysteria. Endocrine 2002;19(2):127-130.

87. Koshiyama H. The impact of statin treatment on diabetic patients. Current Opinion in Investigational Drugs 2003; 4(4): 395-400.

88. Jonsson KB, Zahradnik R, Larsson T, White KE, Sugimoto T, Imanishi Y, Yamamoto T, Hampson G, Koshiyama H, Ljunggren o, Oba K, Yang I M, Miyauchi A, Econs M, Lavigne J, Juppner H, Fibroblast growth Factor 23 in oncogenic osteomalacia and X-linked hypophosphatemic rickets. N Engl J Med 2003; 348(17):1656-1663.

89. Koshiyama H, Fujisawa T, Kuwamura N, Nakamura Y, Kanamori H, Oida E, Hara A, Suzuki T, Sasano H. A Case of Normoreninemic Aldosterone-producing adenoma associated with chronic renal failure: case report and literature review. Endocrine 2003; 21(3):221-226.

90. Bastepe M, Frorich LF, Hendy GN, Indridason OS, Josse RG, Koshiyama H, Korkko J, Nakamoto JM, Rosenbloom AL, Slyper AH, Sugimoto T, Tsatsoulis A, Crawford JD, Juppner H. Autosomal dominant pseduohypoparathyroidisms type Ib is associated with a heterozygous microdeletion that likely disrupts a putative imprinting control element of GNAS. J Clin Invest 2003;112(8):1255-1263 .

91. Koshiyama H, Kuwamura N, Nakamura Y, Shimono D, Seino Y. The relationship of intima-media thickness of carotid artery to mutiple risk factors in Japanese subjects with type 2 diabetes. Atherosclerosis 2003; 4(2 suppl):44..

92. Koshiyama H, Kuwamura N, Nakamura Y, Shimono D, Seino Y. The long-term effects of PPARg agonist in subjects with type 2 diabetes. Atherosclerosis 2003; 4(2 suppl)::216-217.

93. Ihara C, Nakamoto Y, Nakatsuru Y, Yano J, Sakamoto S, Nannao M, Koshiyama H. Usefulness of FDG-PET in detecting an ADH-secreting tumor: a case report (letter). Eur J Intern Med 2004;15:181-182.

94. Nishi Y, Koshiyama H, Honjo S, Seino Y. Poor Correlation of pulse wave velocity and intima-media thickness in diabetic subjects (letter). Diabetes Care 2004; 27(8):2084.

95. Honjo S, Nishi Y, Wada Y, Hamamoto Y, Koshiyama H. Possible beneficial effect of telmisartan on glycemic control in diabetic subjects (letter). Diabetes Care 2005;28(7):498.

96. Yamamoto T, Imanishi Y, Kinoshita E, Nakagomi Y, Shimizu N, Miyauchi A, Satomura K, Koshiyama H, Inaba, Nishizawa Y, Juppner H, Ozono K. The role of fibroblast growth factor 23 for hypophosphatemia and abnormal regulation of vitamin D metabolism in patients with McCune-Albright syndrome. J Bone Miner Res 2005;23(3):231-237.

97. Koshiyama H, Honjo S, Hamamoto Y, Ikeda H, Wada Y. Drugs share antidiabetic and antiathersclerotic actions though “the common soil.” 　Medical Hypotheses 2006;66(3):473-475.

98. Koshiyama H, Ogawa Y, Tanaka K, Tanaka I. The unified hypothesis of interactions among the bone, adipose and vascular systems: ‘osteo-lipo-vascular interactions’. Medical Hypotheses 2006; 66(5):960-963.

99. Kobayashi K, Imanishi Y, Koshiyama H, Miyauchi A, Wakasa K, Goto H, Ohashi H, Koyano H, Mochizuki R, Miki T, Inaba M, Nishizawa Y. Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia. Life Sci 2006; 78(20):2295-2301.

100. Koshiyama H, Honjo S, Hamamoto Y, Wada Y, Ikeda H. Hypothalamic pathogenesis of type 2 diabetes. Medical Hypotheses 2006; 67:307-310.

101. Koshiyama H, Ikeda H, Honjo S, Nakamura Y, Tanaka K, Tsugawa N, Okano T. Hypovitaminosis D is frequent in Japanese subjects with type 2 diabetes (letter). Diabetes Res Clin Pract 2007;76:470-1

102. Koshiyama H, Taniguchi A, Inagaki N, Seino Y. “Cardiometabolic risk” and insulin deficiency in Japanese (letter). Diabetic Medicine 2007; 24(5):571

103. Koshiyama H, Inagaki N, Seino Y. Which we should ADOPT: sulfonylureas or glitazones?(letter) Diabetic Medicine 2007; 24(7):804

104. Nabe K, Honjo S, Ikeda H, Wada Y, Nomura K, Hamamoto Y, Koh T, Tatsuoka Y, Koshiyama H. Diabetes insipidus and cognitive function. Medical Hypotheses 2007; 69:764-766.

105. Arai K,, Nabe K, Ikeda H, Honjo S, Wada Y, Hamamoto Y, Nomura K, Aoki T, Sano T, Koshiyama H. A case of lymphocytic panhypophysitis during pregnancy. Endocrine 2007;32(1)117-121.

106. Takeuchi F, Yanai K, Inomata H, Kuzuya N, Kajio H, Honjo S, Takeda N, Kaburagi Y, Yasuda K, Shirasawa S, Sasazuki T, Kato N. Search of type 2 diabetes susceptibility gene on chromosome 20q.
Biochem Biophys Res Commun. 2007 Jun 15;357(4):1100-6.

107. Koshiyama H, Ogawa Y, Tanaka K, Tanaka I. Diabetes mellitus as dysfunction of interactions
among all organs: “ominous orchestra of organs”. Clinical Medicine: Endocrinology and Diabetes
2008; 1:1-6. http://la-press.com/journal.php?journal_id=65

108. Nabe K, Nomura K, Ikeda H, Honjo S, Wada Y, Kimura T, Aoyama T, Hamamoto Y,
Koshiyama H. Depression is one component of metabolic syndrome Medical Hypotheses
Research 2008;4(2):79-83.
http://www.journal-mhr.com/PDF_Files/vol_4_2/4_2_PDFs/4_2_4.pdf

109. Koshiyama H, Taniguchi A, Tanaka K, Kagimoto S, Fujioka Y, Hirata K, Nakamura Y,
Iwakura A, Hara K, Yamamoto T, Kuroe A, Ohya M, FujimotoS, Hamamoto Y, Honjo S, Ikeda H,
Nabe K, TsudaK, Inagaki N, Seino Y, Kume N. Effects of pitavastatin on lipid profiles and
high-sensitivity CRP in Japanese subjects with hypercholesterolemia :Kansai Investigation
of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN) Investigators.
Journal of Atherosclerosis and Thrombosis 2008; 15(6): 345-350.
http://www.jstage.jst.go.jp/article/jat/15/6/15_345/_article

110. Takeuchi F, Ochiai Y, Serizawa M, Yanai K, Kuzuya N, Kajio H, Honjo S, Takeda N, Kaburagi Y, Yasuda K, Shirasawa S, Sasazuki T, Kato N. Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q.
J Hum Genet. 2008;53(4):314-24.

111. Ikeda H, Nakamura Y, Minamikawa J, Honjo S, Hamamoto Y, Wada Y, Nabe K, Koshiyama
H. Comparison of Effects of Amlodipine and Angiotensin Receptor Blockers on the Intima-media
Thickness of Carotid Arterial Wall (AAA Study: Amlodipine vs ARB in Atherosclerosis Study)
Diabetes Res Clin Pract 2009; 83:117-118.
http://www.ncbi.nlm.nih.gov/pubmed/19070383?ordinalpos=2&itool=EntrezSystem2.PEntrez.
Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

112. Ikeda H, Honjo S, Hamamoto Y, Wada Y, Nabe K, Koshiyama H. Olmesartan reduced microalbuminuria in Japanese subjects with type 2 diabetes. (leter). Diabetes Res Clin Pract
2009; 83: 50-53.
http://www.ncbi.nlm.nih.gov/pubmed/19062123?ordinalpos=4&itool=EntrezSystem2.PEntrez.
Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

113. Kimura T, Ikeda H, Fujikawa J, Nomura K, Aoyama T, Nabe K, Hamamoto Y, Honjo S, Koshiyama H. Usefulness of serum cystatin C as a marker of diabetic nephropathy in Japanese subjects with type 2 diabetes. Diabetes Res Clin Pract 2009 83(2):e58-61.
http://www.ncbi.nlm.nih.gov/pubmed/19118914?ordinalpos=1&itool=EntrezSystem2.PEntrez.
Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

114. Koshiyama H, Ogawa Y, Tanaka K, Tanaka I. Integrated Network Systems and Evolutionary Developmental Endocrinology. Medical Hypotheses 2009.

115. Honjo S, Ikeda H, Kawasaki Y, Wada Y, Hamamoto Y, Aoyama T, Kimura T, Nomura K, Koshiyama H. Efficacy and safety of miglitol:switching study from voglibose in Japanese patients with type 2 diabetes. The Open Diabetes Journal 2009;2:60-61.
http://www.bentham-open.org/pages/b_viewarticIe.php?articleID=2126993&PHPSESSID=df12b81275ee80b8f17a2ed80062324b

116. Koshiyama H, Ogawa Y, Tanaka K, Tanaka I. Integrated Network Systems and Evolutionary Developmental Endocrinology. Medical Hypotheses 2010 ;Jan;74(1):132-8.

117. Nomura K, Hamamoto Y, Takahara S, Kikuchi O, Honjo S, Ikeda H, Wada Y, Nabe K, Okumura R, Koshiyama H. Relationship between Carotid Intima-media thickness and Silent Cerebral Infarction in Japanese Subjects with Type 2 diabetes. Diabetes Care 2010; 33(1):168-170.

118. Hamamoto Y, Akashi T, Inada A, Bonner-Weir S, Weir GC. Lack of evidence for recipient precursor cells replenishing beta cells in transplanted islets.
Cell Transplant. 2010 Aug 17. [Epub ahead of print]

119. Iwasaki Y, Hamamoto Y, Ikeda H, Honjo S, Wada Y, Koshiyama H. Japanese cases of acute onest diabetic ketosis without glutamic acid decarboxylase autoantibody. Endocrine 2010; 37(2):286-288.

120. Kojima Y, Ishida T, Sun L, Yasuda T, Toh R, Rikitake Y, Fukuda A, Kume N, Koshiyama H, Taniguchi A, Hirata KI. Pitavastatin decreases expression of endothelial lipase both in vitro and in vivo. Cardiovasc Res. 2010 15;87(2):385-93.

121. Koshiyama H. Editorial: Low-grade inflammation as trade-off causing chronic complex diseases. Japanese Clinial Medicine 2010;1:3-4
http://www.la-press.com/low-grade-inflammation-as-trade-off-causing-chronic-complex-diseases-article-a2256

122. Kawasaki Y, Hamamoto Y, Koshiyama H. Minireview: Species-specific Actions of Incretin: from the Evolutionary Perspective. Japanese Clinical Medicine 2010;1:5-11.
http://www.la-press.com/species-specific-actions-of-incretin-from-the-evolutionary-perspective-article-a2312

123. Nishi H, Nishi Y, Yagita M, Tamaru Y, Matsumoto S, Koshiyama H. A case of transient ACTH deficiency associated with polymyalgia rheumatic Japanese Clinical Medicine 2010;1:25-27.
http://www.la-press.com/a-case-of-transient-acth-deficiency-associated-with-polymyalgia-rheuma-article-a2410

124. FujiokaY, Fukuda A, IshidaT, Kagimoto S, Nakamura Y, Iwakura A, Hara K, Yamamoto T, Kuroe A, Ohya M, Fujimoto S, Hamamoto Y, Honjo S, Ikeda H, Nabe K, Tsuda K, Taniguchi A, Tanaka K, Koshiyama Hiroyuki H, Kum N, Hirata K-i. Pitavastatin reduces elevated IL-18 levels in Japanese subjects with hypercholesterolemia: Sub-analysis of Kansai Investigation of statin for hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN) Journal of Atherosclerosis and Thrombosis 2011;18:8-15.

125. Wada Y, Hamamoto Y, Nakamura Y, Honjo S, Kawasaki Y, Ikeda H, Shimatsu A, Koshiyama H. Lymphocytic panhypophysitis: its clinical features of Japanese cases. Japanese Clinical Medicine 2011;.2:15-20.
http://www.la-press.com/lymphocytic-panhypophysitis-its-clinical-features-in-japanese-cas-article-a2670

126. Sato S, Masami K, Otsuki S, Tanaka S, Nakayama N, Makita S, Koshiyama H, Nohara R. Post-exercise ankle-brachial pressure index demonstrates altered endothelial function in the elderly. Japanese Clinical Medicine 2011;2:21-24.
http://www.la-press.com/post-exercise-ankle-brachial-pressure-index-demonstrates-altered-endot-article-a2704

127. Hamamoto Y, Koshiyama H. Editorial: ROADMAP and ORIENTAL trials: the re-emergence of J-Curve ghost? Japanese Clinical Medicine 2011; 2-25-28.
http://www.la-press.com/roadmap-and-oriental-trials-the-re-emergence-of-j-curve-ghost-article-a2724

128. Wada Y, Hamamoto Y, Ikeda H, Koshiyama H. Seasonal variations of urinary albuminuria ratio in subjects with type diabetes and nephropathy. Diabetic Medicine (in press)

129. Kanemasa Y, Iwasaki Y, Hamamoto Y, Kawasaki Y, Honjo S, Ikeda H, Wada Y, Koshiyama H. A case of diabetic ketoacidosis associated with Guillain-Barre syndrome Internal Medicine 2011;50(19):2201-5

130 . Iwasaki Y ,Takahaahi M, Nozu K, Matsumoto S, Koshiyama H. A case of Gitelman’s syndrome complicated by CETP deficiency presented with generalized convulsions after influenza A virus infection. Internal Medicine　2011;50(19):2179-83.
http://www.la-press.com/further-possible-mechanisms-of-dipeptidyl-peptidase-4-inhibitors-to-de-article-a2891

131. Koshiyama H. EDITORIAL: Further possible mechanisms of dipeptidyl peptidase-4 inhibitors to decrease blood glucose in subjects with type 2 diabetes. Japanese Clinical Medicine 　2011;2:67-69.

132. Aoyama T, Ikeda H, Honjo S, Nomura K, Wada Y, Hamamoto Y, Fujikawa J, Hayashino Y, Fukuhara S, Koshiyama H. Hetergeneity of adult type 1 diabetes of Japanese subjects depending on titers of autoantibodies to GAD. J 　Diabet　 Invest (in press)

We believe that such a special room is appropriate for the foreign executives living in Japan, who would need privacy and apparatus to continuing the work using internet access during admission. Especially for diabetic patients (both type 1 and type 2), we could provide the short stay schedule in order to examine the complications, such as retinopathy, nephropathy, neuropathy and atherosclerosis, and adjustments of insulin therapy regimen.

The daily cost of them ranges from\30,000 to\100, 000, depending on their apparatus. All of them are equipped with an internet supply, a sink, a telephone, a refrigerator a sofa, and a shower or bath. For their photos and details of equipments, please see the page below (the description is Japanese only, sorry).

Wards