ORIGINAL ARTICLE

1. Tagaya Y, Wakasugi H, Masutani H, Nakamura H, Iwata S, Mitsui A, Fujii S, Wakasugi N, Tursz T, Yodoi J:
Role of ATL-derived factor (ADF) in the normal and abnormal cellular activation. Involvement of dithiol related reduction.
Mol. Immunol. 27: 1279-1289, 1990.

2. Inamoto T, Yamauchi A, Nakamura Y, Nakamura H, Kanai M, Maeda M, Tagaya Y, Yodoi J, Ozawa K:
Hepatocyte Growth Inhibitory Factor (HGI) Derived from HTLV-I(+) T cell Lines; Effect on the Epidermal Growth Factor-dependent Proliferation of Rat Hepatocytes.
Clin. Immunol. Immunopathol. 58: 366-376, 1991.

3. Kusama K, Saitoh T, Masutani H, Nakamura H, Yodoi J, Moro I:
Adult T cell leukemia derived factor (ADF) in oral epithelial lesions.
J. Oral Pathol. Med. 20: 421-424, 1991.

4. Matsuda M, Masutani H, Nakamura H, Miyajima S, Yamauchi A, Yonehara S, Uchida A, Irimajiri K, Horiuchi A, Yodoi J:
Protective Activity of ATL-derived factor (ADF) against tumor necrosis factor-dependent cytotoxicity on U937 cells.
J. Immunol. 147: 3837-3841, 1991.

5. Yamauchi A, Masutani H, Tagaya Y, Wakasugi N, Mitsui A, Nakamura H, Inamoto T, Ozawa K,Yodoi J:
Lymphocyte transformation and thiol compounds; the role of ADF/thioredoxin as an endogenous reducing agent.
Mol. Immunol. 29: 263-270, 1992.

6. Nakamura H, Masutani H, Tagaya Y, Yamauchi A, Inamoto T, Nanbu Y, Fujii S, Ozawa K,Yodoi J:
Expression and growth promoting effect of adult T cell leukemia derived factor, a human thioredoxin homologue in hepatocellular carcinoma.
Cancer 69: 2091-2097, 1992.

7. Masutani H, Naito M, Takahashi K, Hattori T, Koito A, Takatsuki K, Go T, Nakamura H, Fujii S,Yoshida Y, Okuma M, Yodoi J:
Dysregulation of Adult T cell leukemia derived factor (ADF)/thioredoxin in HIV infection: Loss of ADF high producer cells in lymphoid tissues of AIDS patients.
AIDS Res. Hum. Retrovir. 8: 1721-1729, 1992.

8. Kato H, Inamoto T, Nakamura H, Furuke K, Uemoto S, Tanaka K, Ozawa K, Hori T, Yodoi J:
Soluble CD23 as a sensitive marker for Epstein-Barr virus-related disorders after liver transplantation.
Transplantation 56, 1109-1113, 1993.

9. Iwata S, Hori T, Sato N, Ueda-Taniguchi Y, Yamabe T, Nakamura H, Masutani H, Yodoi J:
Thiol-mediated redox regulation of lymphocyte proliferation. Possible involvement of adult T cell leukemia-derived factor　and glutathione in transferrin receptor expression.
J. Immunol. 152: 5633-5642, 1994.

10. Kitaoka Y, Sorachi K, Nakamura H, Masutani H, Mitsui A, Kobayashi F, Mori T, Yodoi J:
Detection of adult T cell leukemia-derived factor / human thioredoxin in human serum.
Immunol. Lett. 41: 155-161, 1994.

11. Nakamura H, Matsuda M, Furuke K, Kitaoka Y, Iwata S, Toda K, Inamoto T, Yamaoka Y,
Ozawa K,Yodoi J:
Adult T cell leukemia-derived factor/ human thioredoxin protects endothelial
F-2 cell injury caused by activated neutrophils or hydrogen peroxide.
Immunol. Lett. 42: 75-80, 1994.

12. Furuke K, Nakamura H, Hori T, Iwata S, Maekawa N, Inamoto T, Yamaoka Y, Yodoi J:
Suppression of adult T cell leukemia-derived factor/human thioredoxin induction by FK506 and cyclosporin A: a new mechanism of immune modulation via redox control.
Int. Immunol. 7: 985-993, 1995.

13. Kobayashi F, Sagawa N, Nanbu Y, Kitaoka Y, Mori T, Fujii S, Nakamura H, Masutani H, Yodoi J:
Biochemical and topological analysis of adult T-cell leukemia-derived factor, human homologue of thioredoxin, in the pregnant human uterus.
Human Reproduction 10: 1603-1608, 1995.

14. U-Taniguchi Y, Furuke K, Masutani H, Nakamura H, Yodoi J:
Cell cycle inhibition of HTLV-I transformed T cell limes by retinoic acid: the possible thrapeutic use of thioredoxin reductaseinhibitors.
Oncology Research 7: 183-189, 1995.

15. Nakamura H, De Rosa S, Roederer M, Anderson MT, Dubs JG, Yodoi J, Holmgren A, Herzenberg LA, Herzenberg LA:
Elevation of plasma thioredoxin levels in HIV-infected individuals.
Int. Immunol. 8: 603-611, 1996.

16. Maurice MM, Nakamura H, van der Voort EAM, van Vliet AI, Staal FJT, Tak PP, Breedveld FC,Verweij CL:
Evidence for a role of an altered redox state in hyporesponsiveness of synovial T cells in rhuematoid arthritis.
J. Immunol. 158: 1458-1465, 1997.

17. Nakamura H, Vaage J, Valen G, Padilla CA, Bjornstedt M, Holmgren A:
Measurements of plasma glutaredoxin and thioredoxin in healthy volunteers and during open heart surgery.
Free Radic Biol. Med. 24: 1176-1186, 1998.

18. Tsuyuki S, Yamauchi A, Nakamura H, Kinoshita K, Gomi T, Tanaka K, Inamoto T, Yamaoka Y:
Possible availability of N-acetylcysteine as an adjunct to cytokine therapy for hepatocellular carcinoma.
Clin. Immunol. Immunopathol. 88: 192-198, 1998.

19. Tsuyuki S, Yamauchi A, Nakamura H, Nakamura Y, Kinoshita K, Gomi T, Kawai Y, Hirose T,Furuke K, Ikai I, Yamaoka Y, Inamoto T:
N-acetylcysteine improves cytotoxic activity of cirrhotic rat liver-associated mononuclear cells.
Int. Immunol. 10: 1501-1508,1998.

20. Ueda S, Nakamura H, Masutani H, Sasada T, Yonehara S, Takabayashi A, Yamaoka Y, Yodoi J:
Redox regulation of caspase-3(-like) protease activity: regulatory roles of thioredoxin and cytochrome c.
J. Immunol. 161: 6689-6695, 1998.

21. Nishiyama A, Ohno T, Iwata S, Matsui M, Hirota K, Masutani H, Nakamura H, Yodoi J:
Demonstration of interaction of thioredoxin with p40phox, a phagocyte oxidase component, using a yeast two-hybrid system.
Immunol. Lett. 68:155-159, 1999.

22. Bertini R, Howard OMZ, Dong H-F, Oppenheim JJ, Bizzarri C, Sergi R, Caselli G, Pagliei S, Romines B, Wilshire JA, Mengozzi M, Nakamura H, Yodoi J, Pekkari K, Guranath R, Holmgren A, Herzenberg LA, Herzenberg LA, Ghezzi P:
Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes and T cells.
J. Exp. Med. 189:1783-1789, 1999.

23. Takashima Y, Hirota K, Nakamura H, Nakamura T, Akiyama K, Cheng FS, Maeda M, Yodoi J:
Differential expression of glutaredoxin and thioredoxin during monocytic differentiation.
Immunol. Lett. 68 :397 - 401, 1999

24. Kawai Y, Yamauchi A, Nakamura H, Nakamura Y, Hirose T, Tsuyuki S, Shinkura N, Okawa K,Iwamatsu A, Maeda Y, Ikai I, Yamaoka Y, Inamoto T.
Hepatocyte growth inhibitory factor derived from HTLV-I(+) T-cell line is identical to IL-6.
Leuk. Res. 23:489-497, 1999.

25. Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Sono H, Gon Y, Yodoi J:
Identification of thioredoxin binding protein-2/vitamin D(3) up-regulated protein -1 as a negative regulator of thioreodixn function and expression.
J. Biol. Chem. 274: 21645-21650, 1999.

26. Nakamura T, Ohno T, Hirota K, Nishiyama A, Nakamura H, Wada H, Yodoi J:
Mouse glutaredoxin - cDNA cloning, high level expression in E. coli and its possible implication in redox regulation of the DNA binding activity in transcription factor PEPB2.
Free Rad. Res. 31: 357-365, 1999.

27. Sasada T, Nakamura H, Ueda S, Sato N, Kitaoka Y, Gon Y, Takabayashi A, Spyrou G, Holmgren A,Yodoi J:
Possible involvement of thioredoxin reductase as well as thioredxoin in cellular sensitivity to cis-Diamminedichloroplatinum (II).
Free Radic. Biol. Med. 27: 504-514, 1999.

28. Hirota K, Murata M, Sachi Y, Takasu T, Nakamura H, Mori K, Yodoi J:
Distinct roles of thioredoxin in the cytoplasm and in the nucleus: a two step mechanism of redox regulation of transcription factor NF-kB.
J. Biol. Chem. 274: 27891-27897, 1999.

29. Maurice MM, Nakamura H, Gringhuis S, Okamoto T, Yoshida S, Kullmann F, Lechner S, van der Voort EAM, Leow A, Versendaal J, Muller-Ladner U, Yodoi J, Tak PP, Breedveld FC, Verweij CL:
Expression of the thioredoxin-thioredoxin reductase system in the inflamed joints of patients with rheumatoid arthritis.
Arthritis Rheum. 42: 2430-2439, 1999

30. Nakamura H*, Bai J, Nishinaka Y, Ueda S, Sasada T, Ohshio G, Imamura M, Takabayashi A, Yamaoka Y, Yodoi J:
Expression of Thioredoxin and Glutaredoxin, Redox-Regulating Proteins, in Pancreatic Cancer Cancer Detect. Prev. 24: 53-60, 2000

31. Shioji K, Kishimoto C, Nakamura H, Toyokuni S, Nakayama Y, Yodoi J, Sasayama S:
Upregulation of thioredoxin expression in giant cell myocarditis in rats
FEBS Lett. 472: 109-113, 2000.

32. Sumida Y, Nakashima T, Yoh T, Nakajima Y, Ishikawa H, Mitsuyoshi H, Sakamoto Y, Okanoue T, Kashima K, Nakamura H, Yodoi J:
Serum thioredoxin levels as indicators of oxidative stress and responses to interferon therapy in patients with hepatitis C virus infection.
J. Hepatol. 33:616-622, 2000

33. Hirota K, Nakamura H, Arai T, Ishii H, Bai J, Itoh T, Fukuda K, Yodoi J:
Geranylgeranylacetone enhances expression of thioredoxin and suppresses ethanol-induced injury in cultured hepatocytes.
Biochem. Biophys. Res. Commun. 275: 825-830, 2000

34. De Rosa SC, Zaretsky MD, Dubs JG, Roederer M, Anderson MT, Mitra D, Watanabe N, Nakamura H, Tjioe I, Deresinski SC, Moore WA, Ela SW, Herzenberg LA and Herzenberg LA:
N-acetylcysteine (NAC) replenishes glutathione in HIV infection
Eur. J. Clin. Invest. 30:915-929, 2000

35. Ueno M, Matsutani Y, Nakamura H, Masutani H, Yagi M, Yamashiro H, Kato H, Inamoto T, Yamauchi A, Takahashi R, Yamaoka Y, Yodoi J:
Possible association of thioredoxin and p53 in breast cancer
Immunol. Lett. 75: 15-20, 2000

36. Yarimizu J, Nakamura H, Yodoi J, Takahashi K:
Efficiency of selenocysteine incorporation in human thioredoxin reductase
Antioxid. Redox Signal. 2: 643-651, 2000

37. Kobayashi M, Nakamura H, Yodoi J, Shiota K:
Immunohistochemical localization of thioredoxin and glutaredoxin in mouse embryos and fetuses
Antioxid. Redox Signal. 2:653-663, 2000

38. Nakashima T, Sumida Y, Yoh T, Kakisaka Y, Nakajima Y, Ishikawa H, Mitsuyoshi H, Kashima K, Nakamura H, Yodoi J:
Thioredoxin levels in the sera of untreated hepatitis patients and those treated with glycyrrhizin or ursodeoxycholic acid.
Antioxid. Redox Signal. 2: 687-694, 2000

39. Sasada T, Nakamura H, Ueda S, Ueno M, Iwata S, Takabayashi A, Yodoi J:
Secretion of Thioredoxin Enhances Cellular Resistance to cis-Diamminedichloroplatinum (II)
Antioxid. Redox Signal. 2: 695-705, 2000

40. Abdiu A, Nakamura H, Sahaf B, Yodoi J, Holmgren A, Rosen A:
Thioredoxin blood level increases after severe burn injury
Antioxid. Redox Signal. 2: 707-716, 2000

41. Nakamura H*, De Rosa SC, , Yodoi J, Holmgren A, Ghezzi P, Herzenberg LA, Herzenberg LA:
Chronic elevation of plasma thioredoxin: inhibition of chemotaxis and curtailment of life expectancy in AIDS.
Proc. Natl. Acad. Sci. USA 98: 2688-2693, 2001

42. Matsuo Y, Akiyama N, Nakamura H, Yodoi J, Noda M, Kizaka-Kondoh S:
Identification of a novel thioredoxin-related transmembrane protein
J. Biol. Chem. 276: 10032-10038, 2001

43. Dekigai H, Nakamura H, Bai J, Tanito M, Masutani H, Hirota K, Matsui H, Murakami M, Yodoi J:
Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes.
Free Radic Res. 35: 23-30, 2001

44. Kishimoto C, Shioji K, Nakamura H, Nakayama Y, Yodoi J, Sasayama S:
Serum thioredoxin (TRX) levels in patients with heart failure
Jpn. Circ. J. 65: 491-494, 2001

45. Miyamoto M, Kishimoto C, Shioji K, Nakamura H, Toyokuni S, Nakayama Y, Kita M, Yodoi J,Sasayama S:
Difference of thioredoxin expression in viral myocarditis in inbred strains of mice
Jpn. Circ. J. 65: 561-564, 2001

46. Hata I, Shigematsu Y, Ohshima Y, Tsukahara H, Fujisawa K, Hiraoka M, Nakamura H, Masutani H, Yodoi J, Kotsuji F, Sudo M, Mayumi M:
Involvement of thioredoxin in the regulation of growth hormone secretion in rat pituitary cell cultures.
Am J. Physiol. Endocrinol. Metab. 281: E269-274, 2001

47. Sumida Y, Nakashima T, Yoh T, Kakisaka Y, Nakajima Y, Ishikawa H, Mitsuyoshi H, Okanoue T, Nakamura H, Yodoi J:
Serum thioredoxin elucidates the significance of serum ferritin as a marker of oxidative stress in chronic liver diseases
Liver 21:295-299, 2001

48. Arner ESJ, Nakamura H, Sasada T, Yodoi J, Holmgren A, Spyrou G:
Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite the glutathione-platinum complex.
Free Radic Biol Med 31: 1170-1178, 2001

49. Matsutani Y, Yamauchi A, Takahashi R, Ueno M, Yoshikawa K, Honda K, Nakamura H,
Kato H, Kodama H, Inamoto T, Yodoi J, Yamaoka Y:
Inverse correlation of thioredoxin expression with estrogen receptor- and p53-dependent tumor growth in breast cancer tissues.
Clin. Cancer Res. 7: 3430-3436, 2001

50. Nishinaka Y, Nakamura H, Okada N, Okada H, Yodoi J:
Redox control of EBV infection: Prevention by thiol-dependent mosdulation of functional CD21/EBV receptor expression.
Antiox. Redox Signal. 3: 1075-1087, 2001

51. Nakamura H*, Herzenberg LA, Bai J, Araya S, Kondo N, Nishinaka Y, Herzenberg LA, Yodoi J:
Circulating thioredoxin suppresses lipopolysaccharide-induced neutrophil chemotaxis
Proc. Natl. Acad. Sci. USA 98: 15143-15148, 2001

52. Sasada T, Nakamura H, Masutani H, Ueda S, Sono H, Takabayashi A, Yodoi J:
Thioredoxin-mediated redox control of human T-cell lymphotropic virus type-I (HTLV-I) gene expression.
Mol. Immunol. 38: 723-732, 2002

53. Jikimoto T, Nishikubo Y, Koshiba M, Kanagawa S, Morinobu S, Morinobu A, Saura R,
Mizuno K, Kondo S, Toyokuni S, Nakamura H, Yodoi J, Kumagai S:
Thioredoxin as a biomarker for oxidative stress in patients with rheumatoid arthritis
Mol. Immunol. 38: 765-772, 2002

54. Ueda S, Nakamura H, Masutani H, Sasada T, Takabayashi A, Yamaoka Y, Yodoi J:
Baicalin induces apoptosis via mitochondrial pathway as prooxidant
Mol. Immunol. 38: 781-791, 2002

55. Sugimoto M, Inoue T, Takeshita K, Nakamura H, Yodoi J:
Effects of a new anti-rheumatic drug KE-298 and its active metabolite; KE-758 on secretion of thioredoxin and on the level of intracellular glutathione in human monocytes and T cells
Mol. Immunol. 38: 793-799, 2002

56. Bai J, Nakamura H, Hattori I, Tanito M, Yodoi J:
Thioredoxin suppresses 1-methyl-4-phenylpyridinium-induced neurotoxicity in PC12 cells
Neurosci. Lett. 321: 81-84, 2002

57. Tanito M, Masutani H, Nakamura H, Yodoi J, Ohira A:
Cytoprotective effect of thioredoxin in retinal photic injury in mice
Invest Ophthalmol. Vis. Sci. 43: 1162-1167, 2002

58. Tanaka T, Hosoi F, Yamaguchi-Iwai Y, Nakamura H, Masutani H, Ueda S, Nishiyama A, Takeda S, Wada H, Spyrou G, Yodoi J:
Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondiral-dependent apoptosis
EMBO J 21: 1695-1703, 2002

59. Kakisaka Y, Nakashima T, Sumida Y, Yoh T, Nakamura H, Yodoi Y, Senmaru H:
Elevation of serum thioredoxin levels in patients with type 2 diabetes
Horm Metab. Res. 34; 160-164, 2002

60. Nakamura H*, Tamura S, Watanabe I, Iwasaki T, Yodoi J:
Enhanced resistancy of thioredoxin- trasngenic mice against influenza virus-induced pneumonia
Immunol. Lett. 82: 165-170, 2002.

61. Tanito M, Masutani H, Nakamura H, Oka S, Ohira A, Yodoi J:
Attenuation of Retinal Photooxidative Damage in Thioredoxin Transgenic Mice
Neurosci Lett. 326: 142-146, 2002

62. Tanito M, Nishiyama A, Tanaka T, Masutani H, Nakamura H, Yodoi J, Ohira A:
Change of redox status and modulation by thiol replenishment in retinal photooxidative damage
Invest Ophthalmol. Vis. Sci. 43: 2392-2400, 2002.

63. Yuan Z, Kishimoto C, Shioji K, Nakamura H, Yodoi J, Sasayama S:
Temocapril treatment ameliorates autoimmune myocarditis associated with enhanced cardiomyocyte thioredoxin expression.
Cardiovasc. Res. 55: 320-328, 2002

64. Sugawara K, Nakamura H*, Kanai M, Iwata S, Kawai Y, Taki Y, Yodoi J, Takabayashi A:
Surgical stress during operation for gastrointestinal cancer increases plasma thioredoxin levels and decreases mitochondrial membrane potential in peripheral blood lymphocytes
Redox Report 7: 165-169, 2002

65. Mitsui A, Hamuro J, Nakamura H, Kondo N, Hirabayashi Y, Ishizaki-Koizumi S, Hirakawa T, Inoue T, Yodoi J:
Overexpression of human thioredoxin in transgenic mice protects oxidative stress and extends life span.
Antioxid. Redox Signal. 4: 693-696, 2002

66. Shioji K, Kishimoto C, Nakamura H, Masutani H, Yuan Z, Oka S, Yodoi J:
Overexpression of thioredoxin-1 in transgenic mice attenuates adriamycin-induced cardiotoxicity
Circulation 106: 1403-1409, 2002

67. Miura-Kobayashi M, Nakamura H, Yodoi J, Shiota K:
Thioredoxin, an anti-oxidant protein, protects mouse embryos from oxidative stress-induced developmental anomalies.
Free Radic. Res. 36: 949-956, 2002

68. Takebe G, Yarimizu J, Saito Y, Hayashi T, Nakamura H, Yodoi J, Nagasawa S, Takahashi K:
A comparative study on the hydroperoxide and thiol specificity of the glutathione peroxidase family and selenoprotein P.
J. Biol. Chem. 277: 41254-41258, 2002

69. Hattori I, Takagi Y, Nozaki K, Kondo N, Bai J, Nakamura H, Hashimoto N, Yodoi J:
Hypoxia-ischemia induces thioredoxin expression and peroxynitrite formation in newborn rat brain.
Redox Rep 7: 256-259, 2002

70. Sumida Y, Nakashima T, Yoh T, Furutani M, Hirohama A, Kakisaka Y, Nakajima Y,
Ishikawa H, Mitsuyoshi H, Okanoue T, Kashima K, Nakamura H, Yodoi J:
Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease.
J. Hepatol. 38: 32-38, 2003

71. Bing Y, Hirao Y, Takenouchi N, Che L, Nakamura H, Yodoi J, Nagai T:
Effects of thioredoxin on the preimplantation development of bovine embryos
Theriogenology 59: 863-873, 2003

72. Bai J, Nakamura H, Kwon YW, Hattori I, Yamaguchi Y, Kim Y-C, Kondo N, Oka S, Ueda S,
Masutani H, Yodoi J:
Critical roles of thioredoxin in the nerve growth factor-mediated signal transduction and neurite outgrowth in PC 12 cells.
J. Neurosci. 23: 503-509, 2003

73. Yamada Y, Nakamura H, Adachi T, Sannohe S, Oyamada H, Kayaba H, Yodoi J, Chihara J:
Elevated serum levels of thioredoxin in patients with acute exacerbation of asthma
Immunol. Lett. 86:199-205, 2003

74. Miwa K, Kishimoto C, Nakamura H, Makita T, Ishii K, Okuda N, Taniguchi A, Shioji K, Yodoi J, Sasayama S:
Increased oxidative stress with elevated serum thioredoxin level in patients with coronary spastic angina.
Clin. Cardiol 26: 177-181, 2003

75. Okuyama H, Nakamura H, Shimahara Y, Araya S, Kawada N, Yamaoka Y, Yodoi J:
Overexpression of thioredoxin prevents acute hepatitis caused by thioacetamide or lipopolysaccharide in mice.
Hepatology 37: 1015-1025, 2003

76. Kato A, Odamaki M, Nakamura H, Yodoi J, Hishida A:
Elevation of blood thioredoxin in hemodialysis patients with hepatitis C virus infection
Kidney Int. 63: 2262-2268, 2003

77. Mahmood S, Yamada G, Niiyama G, Kawanaka M, Togawa K, Sho M, Ito T, Sasagawa T, Okita M, Nakamura H, Yodoi J:
Effect of vitamin E on serum aminotransferase and thioredoxin levels in patients with viral hepatitis C.
Free Radic. Res. 37: 781-785, 2003

78. Shibata T, Yamada T, Ishii T, Kumazawa S, Nakamura H, Masutani H, Yodoi J, Uchida K:
Thioredoxin as a molecular target of cyclopentenone prostaglandins
J. Biol. Chem. 278: 26046-26054, 2003

79. Miyamoto S, Sakamoto T, Soejima H, Shimomura H, Kajiwara I, Kojima S, Hokamaki J, Sugiyama S, Yoshimura M, Ozaki Y, Nakamura H, Yodoi J, Ogawa H:
Plasma thioredoxin levels and platelet aggregability in patients with acute myocardial infarction
Am. Heart J. 146: 465-471, 2003

80. Kawano H, Yasue H, Hirai N, Yoshida T, Fukushima H, Miyamoto S, Kojima S, Hokamaki J,Nakamura H, Yodoi J, Ogawa H:
Effects of transdermal and oral estrogen supplementation on endothelial function, inflammation and cellular redox state.
Int. J. Clin. Pharmacol. Ther. 41: 346-353, 2003

81. Hirai N, Kawano H, Yasue H, Shimomura H, Miyamoto S, Soejima H, Kajiwara I, Sakamoto T, Yoshimura M, Nakamura H, Yodoi J, Ogawa H:
Attenuation of nitrate tolerance and oxidative stress by an angiotensin II receptor blocker in patients with coronary spastic angina.
Circulation 108: 1446-1450, 2003

82. Kasuno K, Nakamura H, Ono T, Muso E, Yodoi J:
Protective roles of thioredoxin, a redox-regulating protein, in renal ischemia/reperfusion injury
Kidney Int. 64: 1273-1282, 2003

83. Hoshino T, Nakamura H, Okamoto M, Kato S, Araya S, Nomiyama K, Oizumi K, Young HA, Aizawa H, Yodoi J:
Redox-active protein thioredoxin prevents proinflammatory cytokine- or bleomycin-induced lung injury.
Am. J. Respir. Crit. Care Med. 168: 1075-1083, 2003

84. Shibata T, Yamada T, Kondo M, Tanahashi N, Tanaka K, Nakamura H, Masutani H, Yodoi J,
Uchida K:
An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effect of 15-deoxy-?12,14-prostaglandin J2 on proteasome
Biochemistry 42: 13960-13968, 2003

85. Murata H, Ihara Y, Nakamura H, Yodoi J, Sumikawa K, Kondo T:
Glutaredoxin exerts an anti-apoptotic effect by regulating the redox state of Akt
J. Biol. Chem. 278: 50226-50233, 2003

86. Soejima H, Suefuji H, Miyamoto S, Kajiwara I, Kojima S, Hokamaki J, Sakamoto T, Yoshimura M, Nakamura H, Yodoi J, Ogawa H:
Increased plasma thioredoxin in patients with acute myocardial infarction
Clin. Cardiol. 26: 583-587, 2003

87. Kondo N, Ishii Y, Kwon YW, Tanito M, Horita H, Nishinaka Y, Nakamura H, Yodoi J:
Redox-sensing release of human thioredoxin from T lymphocytes with negative feedback loops
J. Immnol. 172: 442-448, 2004

88. Miyamoto S, Kawano H, Sakamoto T, Soejima H, Kajiwara I, Hokamaki J, Hirai N,
Sugiyama S, Yoshimura M, Yasue H, Nakamura H, Yodoi J, Ogawa H:
Increased plasma levels of thioredoxin in patients with coronary spastic angina
Antioxid. Redox Signal. 6: 75-80, 2004

89. Hattori I, Takagi Y, Nakamura H, Nozaki K, Bai J, Kondo N, Sugino T, Nishimura M, Hashimoto N, Yodoi J:
Intravenous administration of thioredoxin decreases brain damage following transient focal cerebral ischemia in mice.
Antioxid. Redox Signal. 6: 81-87, 2004

90. Tanito M, Nakamura H, Kwon YW, Teratani A, Masutani H, Shioji K, Kishimoto C, Ohira A, Horie R, Yodoi J:
Enhanced oxidative stress and decreased thioredoxin expression in spontaneously hypertensive rats.
Antioxid. Redox Singal. 6: 89-97, 2004

91. Nishinaka Y, Nishiyama A, Masutani H, Oka S, Ahsan KM, Nakayama Y, Ishii Y, Nakamura H,Maeda M, Yodoi J:
Loss of thioredoxin binding protein-2/vitamin D3 up-regulated protein 1
in human T cell leukemia type-I-dependent T-cell transformation: Implications for adult T-cell leukemia leukemogenesis.
Cancer Res. 64: 1287-1292, 2004

92. Kawanaka M, Mahmood S, Niiyama G, Izumi A, Kamei A, Ikeda H, Suehiro M, Togawa K,
Sasagawa T, Okita M, Nakamura H, Yodoi J, Yamada G:
Control of oxidative stress and reduction in biochemical markers by vitamin E treatment in patients with nonalcoholic steatohepatitis : a pilot study.
Hepatol Res. 29: 39-41, 2004

93. Miyamoto M, Kishimoto C, Nimata M, Nakamura H, Yodoi J:
Thioredoxin, a redox-regulating protein, is expressed in spontaneous myocarditits in inbred strains of mice.
Int. J. Cardiol. 95: 315-319, 2004

94. Miyamoto S, Kawano H, Takazoe K, Soejima H, Sakamoto T, Hokamaki J, Yoshimura M, Nakamura H, Yodoi J, Ogawa H:
Vitamin E improves fibrinolytic activity in patients with coronary spastic angina
Thromb Res 113: 345-351, 2004

95. Sumida S, Nakamura H, Junji Yodoi J:
Thioredoxin induction of peripheral blood mononuclear cells in mice in response to a single bout of swimming exercise.
Gen. Physiol. Biophys. 23: 241-249, 2004

96. Liu W, Nakamura H*, Shioji K, Tanito M, Oka S, Ahsan KM, , Son A, Ishii Y, Kishimoto C, Yodoi J:
Thioredoxin-1 ameliorates myosin-induced autoimmune myocarditis by suppressing chemokine expressions and leukocyte chemotaxis in mice.
Circulation 110: 1276-1283, 2004

97. Bai J, Nakamura H*, Ueda S, Kwon Y-W, Tanaka T, Ban S, Yodoi J:
Proteasome-dependent degradation of cyclin D1 in 1-methyl-4-phenylpyridinium ion (MPP+)-induced cell cycle arrest.
J. Biol. Chem. 279: 38710-38714, 2004

98. Okubo K, Nakamura H, Watanabe J, Kamoto T, Yodoi J, Ogawa O, Nishiyama H:
Overexpression of thioredoxin-1 in transgenic mice attenuates germ cell apoptosis induced by experimental cryptorchidism.
J. Urol. 172: 2479-2482, 2004

99. Okuyama H, Nakamura H, Shimahara Y, Uyama N, Kwon YW, Kawada N, Yamaoka Y, Yodoi J.
Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice
J. Hepatol. 42: 117-123, 2005

100. Miwa K, Kishimoto C, Nakamura H, Makita T, Ishii K, Okuda N, Yodoi J, Sasayama S:
Serum thioredoxin and alpha-tocopherol concentrations in patients with major risk factors
Circ. J. 69: 291-294, 2005

101. Hokamaki J, Kawano H, Soejima H, Miyamoto S, Kajiwara I, Kojima S, Sakamoto T, Sugiyama S, Yoshimura M, Nakamura H, Yodoi J, Ogawa H:
Plasma thioredoxin levels in patients with unstable angina
Int. J. Cardiol. 99: 225-231, 2005

102. Tanito M, Kwon YW, Kondo N, Bai J, Masutani H, Nakamura H, Fujii J, Ohira A, Yodoi J:
Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage
J. Neurosci. 25: 2396-2404, 2005

103. Todoroki Y, Tsukahara H, Ohshima Y, Shukunami K, Nishijima K, Kotsuji F, Hata A, Kasuga K, Sekine K, Nakamura H, Yodoi J, Mayumi M:
Concentrations of thioredoxin, a redox-regulating protein, in umbilical cord blood and breast milk.
Free Radic Res. 39: 291-297, 2005

104. Tanaka T, Nakamura H, Yodoi J, Bloom ET:
Redox regulation of the signaling pathways leading to eNOS phosphorylation
Free Radic. Biol. Med. 38: 1231-1242, 2005

105. Kihara M, Kontani K, Yamauchi A, Miyauchi A, Nakamura H, Yodoi J, Yokomise H:
Expression of thioredoxin in patients with Graves' disease
Int. J. Mol. Med. 15: 795-799, 2005

106. Ichiki H, Hoshino T, Kinoshita T, Imaoka H, Kato S, Inoue H, Nakamura H, Yodoi J, Young HA, Aizawa H:
Thioredoxin suppresses airway hyperresponsiveness and airway inflammation in asthma
Biochem. Biophys. Res. Commun. 334: 1141-1148, 2005

107. Sato H, Ozawa K, Iwata S, Kaihara S, Ogura Y, Fujimoto Y, Ono M, Hodohara K, Uemoto S,
Nakamura H, Takai K, Tanaka K:
Role of Bcl-2 mRNA in homeostatic proliferation in circulating T-cells in human liver transplant patients after T-cell depletion.
J Surg. Res. 127: 123-130, 2005

108. Kawasaki K, Nisho A, Nakamura H, Uchida K, Fukui T, Ohana M, Yoshizawa H, Ohashi S,
Tamaki H, Matsuura M, Asada M, Nishi T, Nakase H, Toyokuni S, Liu W, Yodoi J, Okazaki K,Chiba T:
Helicobacter felis-induced gastritis was suppressed in mice overexpressing thioredoxin-1
Lab. Invest. 85: 1104-1117, 2005

109. Ahsan MK, Nakamura H*, Tanito M, Yamada K, Utsumi H, Yodoi J:
Thioredoxin-1 suppresses lung injury and apoptosis induced by diesel exhaust particles (DEP) by scavenging reactive oxygen species and by inhibiting DEP-induced down regulation of Akt
Free Radic. Biol. Med. 39: 1549-1559, 2005

110. Kim SJ, Miyoshi T, Taguchi T, Tamaki Y, Nakamura H, Yodoi J, Kato K, Noguchi S:
High thioredoxin expression is associated with resistance to docetaxel in primary breast cancer
Clin. Cancer Res. 11: 8425-8430, 2005

111. Miyamoto S, Kawano H, Hokamaki J, Soejima H, Kojima S, Kudoh T, Nagayoshi Y, Sugiyama S, Sakamoto T, Yoshimura M, Nakamura H, Yodoi J, Ogawa H:
Increased plasma levels of thioredoxin in patients with glucose intolerance
Intern. Med. 44: 1127-1132, 2005

112. Oka S, Liu W, Masutani H, Hirata H, Shinkai Y, Yamada S, Yoshida T, Nakamura H, Yodoi J:
Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP2)-deficient mice: a unique animal model of Reye syndrome
FASEB J. 20: 121-123, 2006

113. Ohashi S, Nishio A, Nakamura H, Kido M, Ueno S, Uza N, Inoue S, Kitamura H, Kiriya K, Asada M, Tamaki H,
Matsuura M, Kawasaki K, Fukui T, Watanabe N, Nakase H, Yodoi J, Okazaki K, Chiba T:
Protective roles of redox-active protein thioredoxin-1 for severe acute pancreatitis
Am. J. Physiol. Gastrointest. Liver Physiol. 290: G772-G781, 2006

114. Wang D, Masutani H, Oka S, Tanaka T, Yamaguchi-Iwai Y, Nakamura H, Yodoi J:
Control of mitochondrial outer membrane permeabilization and Bcl-xL levels by thioredoxin 2 in DT40 cells.
J. Biol. Chem. 281: 7384-7391, 2006

115. Son A, Nakamura H, Kondo N, Matsuo Y, Liu W, Oka S, Ishii Y, Yodoi J:
Redox regulation of mast cell histamine release in thioredoxin-1 (TRX) transgenic mice
Cell Res. 16: 230-239, 2006

116. Ohashi S, Nishio A, Nakamura H, Kido M, Kiriya K, Asada M, Tamaki H, Fukui T, Kawasaki K, Watanabe N, Nakase H, Yodoi J, Okazaki K, Chiba T:
Clinical significance of serum thioredoxin-1 levels in patients with acute pancreatitis
Pancreas 32: 264-270, 2006

117. Tsuji G, Koshiba M, Nakamura H, Kosaka H, Hatachi S, Kurimoto C, Kurosaka M, Hayashi Y,
Yodoi J, Kumagai S:
Thioredoxin protects against joint destruction in a murine arthritis model
Free Radic. Biol. Med. 40: 1721-1731, 2006

118. Callister M.E, Burke-Gaffney A, Quinlan G.J, Nicholson A.G, Florio R, Nakamura H, Yodoi J,
Evans T.W:
Extracellular thioredoxin levels are increased in patients with acute lung injury
Thorax 61: 521-527, 2006

119. Inomata Y, Nakamura H*, Tanito M, Teratani A, Kawaji T, Kondo N, Yodoi J, Tanihara H:
Thioredoxin inhibits NMDA-induced neurotoxicity in the rat retina
J. Neurochem. 98: 372-385, 2006

120. Ueda S, Nakamura T, Yamada A, Teratani A, Matsui N, Furukawa S, Hoshino Y, Narita M, Yodoi J, Nakamura H*:
Recombinant human thioredoxin suppresses lipopolysaccharide-induced bronchoalveolar neutrophil infiltration in rat.
Life Sci. 79: 1170-1177, 2006

121. Sato A, Hara T, Nakamura H, Kato N, Hoshino Y, Kondo N, Mishima M, Yodoi J:
Thioredoxin-1 suppresses systemic inflammatory responses against cigarette smoking
Antioxid. Redox Signal. 8: 1891-1896, 2006

122. Ohashi S, Nishio A, Nakamura H, Asada M, Tamaki H, Kawasaki K, Fukui T, Yodoi J, Chiba T:
Overexpression of redox active protein thioredoxin-1 prevents development of chronic pancreatitis in mice
Antioxid. Redox Signal. 8: 1835-1845, 2006

123. Tamaki H, Nakamura H, Nishio A, Nakase H, Ueno S, Uza N, Kido M, Inoue S, Mikami S, Asada M, Kiriya K, Kitamura H, Ohashi S, Fukui T, Kawasaki K, Matsuura M, Ishii Y, Okazaki K, Yodoi J, Chiba T:
Human thioredoxin-1 ameliorates experimental murine colitis in association with suppressed macrophage inhibitory factor production.
Gastroenterology 131: 1110-1121, 2006

124. Miyazaki Y, Kawano H, Yoshida T, Miyamoto S, Hokamaki J, Nagayoshi Y, Yamabe H, Nakamura H, Yodoi J, Ogawa H:
Pancreatic B-cell function is altered by oxidative stress induced by acute hyperglycaemia
Diabet. Med. 24: 154-160, 2007

125. Bai J, Nakamura H*, Kwon YW, Tanito M, Ueda S, Hattori I, Ban S, Momoi T, Kitao Y,
Ogawa S, Yodoi J:
Does Thioredoxin-1 prevent mitochondria- and endoplasmic reticulum-mediated neurotoxicity of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine?
Antioxid. Redox Signal. 9: 603-608, 2007

126. Hamada Y, Miyata S, Nii-Kono T, Kitazawa R, Kitazawa S, Higo S, Fukunaga M, Ueyama S,Nakamura H, Yodoi J, Fukunaga M, Kasuga M:
Overexpression of thioredoxin1 in transgenic mice suppresses development of diabetic nephropathy.
Nephrol. Dial. Transpl. 22: 1547-1557, 2007

127. Matsuura T, Harrison RA, Westwell AD, Nakamura H, Martynyuk AE, Sumners C:
Basal and angiotensin II-inhibited neuronal delayed rectifier K+ current are regulated by thioredoxin.
Am. J. Physiol. Cell Physiol. 293:C211-C217, 2007

128. Tan A, Nakamura H*, Kondo N, Tanito M, Kwon YW, Ahsan MK, Matsui H, Narita M, Yodoi J:
Thioredoxin-1 attenuates indomethacin-induced gastric mucosal injury in mice
Free Radic. Res. 41: 861-867, 2007

129. Hara T, Kondo N, Nakamura H, Okuyama H, Mitsui A, Hoshino Y, Yodoi J:
Cell surface thioredoxin-1; possible involvement in thiol-mediated leukocyte-endothelial cell interaction through lipid rafts.
Antioxid. Redox Signal. 9: 1427-1437, 2007

130. Kondo N, Ishii Y, Kwon YW, Tanito M, Sakakura-Nishiyama J, Mochizuki M, Maeda M,
Suzuki S, Kojima M, Kim YC, Son A, Nakamura H, Yodoi J:
Lipid-raft-mediated uptake of cysteine-modified thioredoxin-1: apoptosis enhancement by inhibiting the endogenous thioredoxin-1
Antioxid. Redox Signal. 9: 1439-1448, 2007

131. Hoshino Y, Nakamura T, Sato A, Mishima M, Yodoi J, Nakamura H:
Neurotropin demonstrates cytoprotective effects in lung cells through the induction of thioredoxin-1.
Am. J. Respir. Cell. Mol. Biol. 37: 438-446, 2007

132. Nakamura T, Hoshino Y, Yamada A, Teratani A, Furukawa S, Okuyama H, Ueda S, Wada H, Yodoi J, Nakamura H*:
Recombinant human thioredoxin-1 becomes oxidzed in circulation and suppresses
bleomycin-induced neutrophil recruitment in the rat airway
Free Radic Res. 41: 1089-1098, 2007

133. Yamada T, Iwasaki Y, Nagata K, Fushiki S, Nakamura H, Marunaka Y, Yodoi J:
Thioredoxin-1 protects against hyperoxia-induced apoptosis in cells of the alveolar walls
Pulm. Pharmacol. Ther. 20:650-659, 2007

134. Kurimoto C, Kawano S, Tsuji G, Hatachi S, Jikimoto T, Sugiyama D, Kasagi S, Komori T, Nakamura H, Yodoi J, Kumagai S:
Thioredoxin may exert a protecitve effect against tissue damage caused by oxidative stress in salivary glands of patients with Sjogren’s syndrome
J. Rheumatol. 34: 2035-2043, 2007

135. Sakuma K, Nakamura H, Nakamura T, Hoshino Y, Ueda S, Ichikawa M, Tabata C, Fujita S, Masago K, Yodoi J, Mishima M, Mio T:
Elevation of serum thioredoxin in patients with gefitinib-induced interstitial lung disease
Intern Med 46: 1905-1909, 2007

136. Takahashi K, Chin K, Nakamura H, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Fukuhara S, Yodoi J, Mishima M:
Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure
Antioxid. Redox. Signal. 10: 715-726, 2008

137. Sato A, Hoshino Y, Hara T, Muro S, Nakamura H, Mishima M, Yodoi J:
Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice.
J. Pharmacol. Exp. Ther. 325: 380-388, 2008

138. Son A, Nakamura H, Okuyama H, Oka S, Yoshihara E, Liu W, Matsuo Y, Kondo N, Masutani H, Ishii Y, Iyoda T, Inaba K, Yodoi J:
Dendritic cells derived from TBP-2 deficient mice are defective to induce T cell responses
Eur. J. Immunol. 38: 1358-1367, 2008

139. Nishihira K, Yamashita A, Imamura T, Hatakeyama K, Sato Y, Nakamura H, Yodoi J, Ogawa H, Kitamura K, Asada Y:
Thioredoxin in coronary culprit lesions: possible relationship to oxidative stress and intraplaque hemorrhage
Atherosclerosis 201:360-367, 2008

140. Inomata Y, Tanihara H, Tanito M, Hoshino Y, Okuyama H, Kinumi T, Kawaji T, Kondo N, Yodoi J, Nakamura H*:
Suppression of choroidal neovasularization by thioredoxin 1 via interaction with complement factor H
Invest. Ophthalmol. Visual Sci. 49:5118-5125, 2008

141. Zhu X, Sato EF, Wang Y, Nakamura H, Yodoi J, Inoue M:
Acetyl-L-carnitine suppresses apoptosis of thioredoxin-2-deficient DT40 cells
Arch Biochem Biophys 478:154-160, 2008

142. Kobayashi N, Ito W, Yamada Y, Ueki S, Kayaba H, Nakamura H, Yodoi J, Chihara J:
Thioredoxin reduces C-C chemokine-induced chemotaxis of human eosinophils.
Allergy64: 1130-1135, 2009

143. Hofer S, Rosenhagen C, Nakamura H, Yodoi J, , Bopp C, Zimmermann J, Goebel M, Schemmer P, Hoffmann K Schltze-Osthoff K, Breitkreutz R, Weigand MA:
Thioredoxin in human and experimental sepsis
Crit. Care Med. 37:2155-2159, 2009

144. Fukunaga A, Horikawa T, Ogura K, Taguchi K, Yu X, Funasaka Y, Takeda M, Nakamura H,
Yodoi J, Nishigori C:
Thioredoxin suppresses the contact hypersensitivity response by inhibiting leukocyte recruitment during the elicitation phase.
Antioxid. Redox Signal. 11:1227-1235, 2009

145. Zhang J, Chen F, Nakamura T, Fujinaga T, Aoyama A, Hamakawa H, Sakai H, Hoshino Y, Yodoi J Wada H, Bando T, Nakamura H*:
Protective effect of thioredoxin perfusion but not inhalation in warm ischemic-reperfused rat lungs
Redox Rep 14:75-81, 2009

146. Ahsan MK, Okuyama H, Hoshino Y, Oka S, Masutani H, Yodoi J, Nakamura H:
Thioredoxin binding protein-2 deficiency enhances methionine-choline deficient diet-induced hepatic steatosis but inhibits steatohepatitis in mice
Antioxid. Redox Signal. 11:2573-2584, 2009

147. Okuyama H, Yoshida T, Son A, Oka S, Wang D, Nakayama R, Masutani H, Nakamura H, Nabeshima Y, Yodoi J:
Thioredoxin binding protein 2 modulates natural killer T cell-dependent innate immunity in the liver: possible link to lipid metabolism
Antioxid. Redox Signal. 11:2585-2593, 2009

148. Son A, Kato N, Horibe T, Matsuo Y, Mochizuki M, Mitsui A, Kawakami K, Nakamura H, Yodoi J:
Direct association of thioredoxin-1 (TRX) with macrophage migration inhibitory factor (MIF), Regulatory role of TRX on MIF internalization and signaling
Antioxid. Redox Signal. 11:2595-2605, 2009

149. Luo F, Wang S, Li K, Nakamura H, Yodoi J, Bai J:
Panaxatriol saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity
J. Ethnopharmacol. 127:419-423, 2010

150. Oka S, Liu W, Yoshihara E, Ahsan KM, Adriana D, Ramos L, Son A, Okuyama H, Zhang L, Masutani H, Nakamura H, Yodoi J:
Thioredoxin binding protein-2 mediates metabolic adaptation in response to lipopolysaccharide in vivo.
Crit. Care Med. 38:2345-2351, 2010



BOOK

1. Kusama K, Moro I, Masutani H, Nakamura H, Yodoi J:
Adult T-cell Leukemia Derived Factor (ADF) in Oral Pathological Lesions.
In "Frontiers of Mucosal Immunology Vol.1." Edited by Tsuchiya M, Nagura H, Hibi T, Moro I. Excerpta Medica, Amsterdam, pp387-388, 1991.

2. Masutani H, Nakamura H, Ueda Y, Kitaoka Y, Kawabe T, Iwata S, Mitsui A, Yodoi J:
ADF(Adult T cell Leukemia-Derived Factor)/ Human Thioredoxin and Viral Infection: Possible New Therapeutic Approach.
In “Microbial Infections” Edited by H. Friedman, et al., Prenum Press, New York,pp265-274, 1992.

3. Matsuda M, Masutani H, Taniguchi Y, Kawabe T, Nakamura H, Iwata S, Nakamura K, Hori T, Okamoto T, Irimajiri K, Horiuchi A, Yodoi J:
Redox signal in immune responses.
In "Molecular Basis of Immune Responses" edited by Saito H, Nariuchi H, Okada H, Okumura K,Takatsuki K, Yodoi J, Nishida M. pp181-194, 1993.

4. Furuke K, Yamauchi A, Nakamura H, Kato H, Inamoto T, Yodoi J:
ATL-derived factor (ADF)/thioredoxin expression in allogenic immune responses:
Mixed lymphocyte reaction of human PBMCs and acute rejection in rat liver allograft.
In "Current Topics in Mucosal Immunology 1993" edited by Tsuchiya M, et al. Elsevier Science B.V. pp257-260, 1994.

5. Iwata S, Matsuda M, Sugie K, Maeda Y, Kawabe T, Nakamura H, Masutani H, Hori T, Yodoi J:
Signal transduction via Fc receptors; involvement of tyrosine kinase and redox regulation by ADF.
In "Advances in Mucosal Immunology" edited by Mestecky J, et al.
Plenum Press, New York, USA. pp659-662, 1995.

6. Nakamura H, Furuke K, Matsuda M, Inamoto T, Ozawa K, Yodoi J:
Adult T cell leukemia-derived factro as an endogenous radical scavenger.
In "Advances in Mucosal Immunology" edited by Mestecky J, et al.
Plenum Press, New York, USA. pp909-911, 1995.

7. Nakamura H, Bjornstedt M, Holmgren A:
Escherichia coli Thioredoxin.
In. "Guidebook to Molecular Chaperones and Protein Folding Factors "
edited by Gething M-J, Oxford University Press, London, pp314-316, 1997.

8. Nakamura H, Aslund F, Holmgren A:
Escherichia coli Glutaredoxin.
In. "Guidebook to Molecular Chaperones and Protein Folding Factors "
edited by Gething M-J, Oxford University Press, London, pp316-318, 1997.

9. Nakamura H, Bjornstedt M, Holmgren A:
Mammalian Thioredoxin.
In. "Guidebook to Molecular Chaperones and Protein Folding Factors "
edited by Gething M-J, Oxford University Press, London, pp343-345, 1997.

10. Nakamura H, Aslund F, Bjornstedt M, Holmgren A:
Mammalian Glutaredoxin.
In. "Guidebook to Molecular Chaperones and Protein Folding Factors "
edited by Gething M-J, Oxford University Press, London, pp346-347, 1997.

11. Holmgren A, Arner E, Aslund F, Bjornstedt M, Zhong L, Ljung J, Nakamura H, Nikitovic D:
Redox regulation by the thioredoxin and glutaredoxin systems.
In. "Oxidative Stress, Cancer, AIDS and Neurodegenerative Diseases." edited by
Montagnier L, Olivier R, Pasquier C., Marcel Dekker Inc., New York, pp 229-246, 1998.

12. Maurice MM, van der Voort EAM, van Vliet AI, Tak PP, Breedveld FC, Verweij CL, Nakamura H, Thorell S.
Chronic oxidative stress in Rheumatoid Arthritis: implications for T cell function.
In. "Oxidative Stress, Cancer, AIDS and Neurodegenerative Diseases." edited by
Montagnier L, Olivier R, Pasquier C.,　Marcel Dekker Inc., New York, pp 537-546, 1998.

13. Ohno T, Hirota K, Nakamura H, Masutani H, Sasada T, Yodoi J:
Thioredoxin and its involvement in the redox regulation of transcription factors, NF-kB and AP-1.
In. "Oxygen Homeostasis and Its Dynamics." edited by Ishimura Y, Shimada H, Suematsu M, Springer-Verlag Tokyo, Tokyo, Japan, pp450-456, 1998.

14. Kumagai S, Nishikubo Y, Jikimoto T, Morita S, Matsuo T, Nakamura H, Yodoi J:
Thioredoxin / ADF (adult T cell leukemia derived factor) as an indicator of oxidative stress.
In "XX World Congress of Pathology and Laboratory Medicine" edited by Melo E, Moduzzi Editore, Bologna, Italy, pp101-106, 1999

15. Nakamura H, Masutani H, Yodoi J:
Thioredoxin-dependent redox regulation in biological responses
In "Free Radicals in Chemistry, Biology and Medicine" edited by Yoshikawa T,
Toyokuni S,Yamamoto Y, Naito Y. OICA International, London, pp172-181, 2000

16. Masutani H, Nishiyama A, Kwon Y-W, Kim Y-C, Nakamura H, Yodoi J:
Redox regulation of gene expression and transcription factors in response to environmental oxidants.
In "Environmental stressors: Effects on Lung, Skin, Eye and Immune System Function" edited by Fuchs J and Packer L, Marcel Dekker Inc. New York, pp. 115-134, 2000.

17. Nakamura H, Kondo N, Bai J, Yodoi J:
Thioredoxin-dependent redox regulation in infection and inflammation
In "XI Biennial Meeting of the Society for Free Radical Research International" edited by Pasquire C, Monduzzi Editore, Paris, pp255-258, 2002

18. Hattori I, Nakamura H, Masutani H, Nishinaka Y, Mitsui A, Yodoi J:
Thioredoxin-dependent redox regulation -- Implications in aging and neurodegenerative diseases
In "Critical reviews of oxidatives stress and aging. Advances in basic science, diagnostics and intervention" edited by Cutler RG and Rodriguez H, World Scientific, Singapore, pp87-101, 2003

19. Shioji K, Nakamura H, Kishimoto C, Yuan Z, Yodoi J:Protection of cell injury by thioredoxin
"Cardiomyopathies and Heart Failure: Biomolecular, Infectious and Immune Mechanisms"
edited by Matsumori A. Kulwer Academic Publisher, Norwell, MA pp457-468, 2003

20. Nakamura H, Kondo N, Hirota K, Masutani H, Yodoi J:
Thiols and Thioredoxin in Cellular Redox Control
In "Redox Genome Interactions in Health and Disease" edited by Fuchs J and Packer L, Marcel Dekker, Inc., New York, pp61-77, 2003

21. Yodoi J, Nakamura H, Masutani H, Nishinaka Y, Hattori I:
The role of thioredoxin in regulatory cellular functions
In "Cellular Implications of Redox Signaling" edited by Gitler C and Danon A, Imperial College Press, London, pp115-140, 2003

22. Liu W, Nakamura H, Shioji K, Tanito M, Oka S, Yodoi J:
Thioredoxin attenuates cardiac myosin-induced autoimmune mayocarditits in mice
In "Immunology 2004 Autoimmunity, Genetic and Degenerative Disorders, Malignancies, and Transplantation", Monduzzi Editore, Italy pp127-130, 2004

23. Ueda S, Nakamura H, Nakamura T, Yodoi J:
Redox regulation of inflammatory tissue damage by thioredoxin
In “Oxidative stress, inflammation and health” edited by Surh Y-J and Packer L, Marcel Dekker, pp41-60, 2005

24. Ahsan MK, Utsumi H, Yodoi J, Nakamura H:
Redox regulation of diesel exhaust particles-induced acute lung injury by thioredoxin-1
In “Proceedings of the 3rd ISMNS and 2nd Meeting SFRR Asia”
Monduzzi Editore, Italy, pp 57-59, 2005

25. Inomata Y, Nakamura H, Tanito M, Teratani A, Kawaji T, Kondo N, Yodoi J, Tanihara H:
Thioredoxin inhibits NMDA-induced retinal neurotoxicity in rat
8th International Congress of Neuroimmunology Monduzzi Editore, Italy, pp 383-385, 2006

26. Nakamura H*:
Extracellular functions of thioredoxin
The Biology of Extracellular Molecular Chaperones:
Novartis Foundation Symposium No. 291 Novartis Foundation, Wiley, pp 184-192, 2008

27. Ahsan MK, Nakamura H, Yodoi J:
Redox regulation by thioredoxin in cardiovascular diseases
In “Handbook of Redox Signaling”, edited by Dipak Das, Mary Ann Liebert, Inc., pp157-162, 2009

REVIEW

1. Nakamura H, Furuke K, Inamoto T, Ozawa K, Yodoi J:
Adult T cell leukemia-derived factor (ADF)/ human thioredoxin in the digestive system: possible new therapeutic approach.
Mucosal Immunology Update 1(2): 4-7, 1993.

2. Nakamura H, Nakamura K, Yodoi J:
Redox regulation of cellular activation.
Annu. Rev. Immunol. 15: 351-369, 1997.

3. Ueda S, Nishiyama A, Nakamura H, Masutani H, Yodoi J:
Cell death and redox regulation.
Photomedicine and Photobiology 19: 39-40, 1997.

4. Nakamura H and Yodoi J:
Redox regulation by thioredoxin in host defense.
Current Trends in Immunology 1: 133-140, 1998.

5. Nishiyama A, Nakamura H, Masutani H, Yodoi J:
Redox regulation of signal transduction by thioredoxin
Photomedicine and Photobiology 20: 9-10, 1998.

6. Ueno M, Ueda S, Nakamura H, Masutani H, Yodoi J:
TRX superfamily and p53 against oxidative stresses
Recent Research Developments in Immunology 2: 375-381, 2000

7. Tanaka T, Nakamura H, Nishiyama A, Masutani H, Wada H, Yodoi J:
Redox regulation by thioredoxin superfamily; protection against oxidative stress and aging
Free Radic Res. 33: 851-855, 2000

8. Nishinaka Y, Nakamura H, Masutani H, Yodoi J:
Redox Control of Cellular Function by Thioredoxin; New Therapeutic Direction in Host Defense
Archivum Immunologiae et Therapeutiae Experimentalis 49: 285-292, 2001

9. Nishiyama A, Masutani H, Nakamura H, Nishinaka Y, Yodoi J:
Redox regulation by thioredoxin and thioredoxin-binding proteins
IUBMB Life 52: 29-33, 2001

10. Nishinaka Y, Masutani H, Nakamura H, Yodoi J:
Regulatory roles of thioredoxin in oxidative stress-induced cellular responses
Redox Report 6: 289-295, 2001

11. Yodoi J, Masutani H, Nakamura H:
Redox regulation by the human thioredoxin system
BioFactors 15: 107-111, 2001

12. Kobayashi M, Nakamura H, Yodoi J, Shiota K:
Ontogenesis of anti-oxidative enzymes in mouse embryos and fetuses: an immunohistochemical study
Ital J Anat Embryol 106: 137-142, 2001

13. Nishinaka Y, Nakamura H, Yodoi J:
Cytokine action of thioredoxin
Methods in Enzymology 347: 332-337, 2002.

14. Nakamura H, Mitsui A, Yodoi J:
Thioredoxin overexpression in transgenic mice
Methods in Enzymology 347: 436-440, 2002.

15. Yodoi J, Nakamura H, Masutani H:
Redox regulation of stress signals: possible roles of dentritic stellate TRX producer cells (DST cell types).
Biological Chemistry 383: 585-590, 2002

16. Hirota K, Nakamura H, Masutani H, Yodoi J:
Thioredoxin superfamily and thioredoxin inducing agents.
Ann. N Y Acad. Sci. 957: 189-199, 2002

17. Ueda S, Masutani H, Nakamura H, Tanaka T, Ueno M, Yodoi J:
Redox control of cell death
Antioxi. Redox Signal. 4: 405-414, 2002

18. Nakamura H, Masutani H, Yodoi J:
Redox imbalance and its control in HIV infection
Antiox. Redox Signal. 4: 455-464, 2002

19. Matsuo Y, Hirota K, Nakamura H, Yodoi J:
Redox regulation by thioredoxin and its related molecules
Drug News and Prospectives 15: 575-580, 2002

20. Yuan Z, Kishimoto C, Shioji K, Nakamura H, Yodoi J, Sasayama S:
Temocapril treatment ameliorates autoimmune myocarditis in rats associated with enhanced cardiomyocyte thioredoxin expression
Mol. Cell. Biochem. 248: 185-192, 2003

21. Kwon Y-W, Masutani H, Nakamura H, Ishii Y, Yodoi J:
Redox regulation of cell growth and cell death
Biological Chemistry 384: 991-996, 2003

22. Yoshida T, Oka S, Masutani H, Nakamura H, Yodoi J:
The role of thioredoxin in the aging process- involvment of oxidative stress
Antioxid. Redox Signal. 5: 563-570, 2003

23. Shioji K, Nakamura H, Masutani H, Yodoi J:
Redox regulation by thioredoxin in cardiovascular diseases
Antioxid. Redox Signal 5: 795-802, 2003

24. Okuyama H, Shimahara Y, Nakamura H, Araya S, Kawada N, Yamaoka Y, Yodoi J:
Thioredoxin prevents thioacetamide-induced acute hepatitis
Comp. Hepatol. 3(Suppl 1): S6, 2004

25. Nakamura H*:
Thioredoxin as a key molecule in redox signaling
Antioxid. Redox Signal. 6:15-17, 2004

26. Nakamura T, Nakamura H, Hoshino T, Ueda S, Wada H, Yodoi J:
Redox regulation of lung inflammation by thioredoxin
Antioxid. Redox Signal 7: 61-70, 2005

27. Nakamura H*:
Thioredoxin and its related molecules; update 2005
Antioxid. Redox Signal. 7: 823-828, 2005

28. Burke-Gaffney A, Callister M.E, Nakamura H:
Thioredoxin: friend or foe in human disease?
Trends Pharmacol. Sci. 26: 398-404, 2005

29. Yoshida T, Nakamura H, Masutani H, Yodoi J:
The involvement of thioredoxin and thioredoxin binding proptein 2 on cellular proliferation and aging process
Annu. N. Y. Acad Sci. 1055: 1-12, 2005

30. Kondo N, Nakamura H, Masutani H, Yodoi J:
Redox regulation of human thioredoxin network
Antioxid. Redox Signal. 8: 1881-1890, 2006

31. Yoshida T, Kondo N, Oka S, Ahsan MK, Hara T, Masutani H, Nakamura H, Yodoi J:
Thioredoxin binding protein-2 (TBP-2): its potential roles in the aging process
Biofactors 27: 47-51, 2006

32. Nakamura H*, Masutani H, Yodoi J:
Extracellular thioredoxin and thioredoxin binding protein-2 in control of cancer
Semin. Cancer Biol. 16: 444-451, 2006

33. Kobayashi-Miura M, Shioji K, Hoshino Y, Nakamura H, Masutani H, Yodoi J:
Oxygen sensing and redox signaling ? the role of thioredoxin in embryonic development and cardiac diseases.
Am. J. Physiol. Heart. Circ. Physiol. 292: H2040-H2050, 2007

34. Hoshino Y, Shioji K, Nakamura H, Masutani H, Yodoi J:
From oxygen sensoring to heart failure- role of thioredoxin
Antioxid. Redox Signal. 9: 689-699, 2007

35. Ahsan MK, Nakamura H, Masutani H, Yodoi J:
Thioredoxin and thioredoxin-binding protein-2 in cancer and metabolic syndrome
Free Radic. Biol. Med. 43: 861-868, 2007

36. Okuyama H, Son A, Ahsan MK, Masutani H, Nakamura H, Yodoi J:
Thioredoxin and thioredoxin binding protein 2in the liver
IUBMB Life 60:656-660, 2008

37. Nakamura H*, Hoshino Y, Okuyama H, Matsuo Y, Yodoi J:
Thioredoxin 1 delivery as a new therapeutics
Adv Drug Deliv Rev 61:303-309, 2009

38. Watanabe R, Nakamura H, Masutani H, Yodoi J:
Anti-oxidative, anti-cancer and anti-inflammatory actions by thioredoxin 1 and thioredoxin-binding protein-2
Pharmacol. Ther. 127: 261-270, 2010