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| <EDUCATION> | |||
| Date | Discipline | Degree | Institution |
| 1976 | Medicine | M.D. | Kyoto Prefectural University of Medicine |
| 1984 | Nephrology | Ph.D. | Kyoto University |
| <POSTDOCTORAL TRAINING> | |||
| Dates | Field of Research | Place | Title |
| 1976-1980 | Internal Medicine | Kyoto City Hospital | Resident |
| 1980-1984 | Nephrology & Immunology | Internal Medicine, Kyoto University |
Medical Staff, |
| 1984-1985 | Immunology | Necker Hospital, Paris, France |
French National Scholarship Fellow |
| 1985 | Immunology | Centre Nationale de la Recherche Scientifique(CNRS), Paris, France |
Visiting Associate |
| <POSITION HELD> | |||
| Dates | Position | Institution | |
| 1986-1992 | Instructor, Department of Internal Medicine |
Kyoto University | |
| 1992-2001 | Assistant Professor, Nephrology Division, Cardiovascular Medicine |
Kyoto University | |
| 2001-Present | Director, Department of Nephrology and Dialysis |
Kitano Hospital Medical Research Institute | |
| 2004-Present | Associate Director of Research Institute | Kitano Hospital Medical Research Institute | |
| 2005-Present | Clinical Professor, Faculty of Medicine |
Kyoto University | |
| <PROFESSIONAL SOCIETIES> | |||
| Boards: | Japanese Society of Internal Medicine, Japanese Society of Nephrology Japanese Society of Apheresis Japan Network for Organ Transplantation The Kidney Foundation, Japan |
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| <MAJOR RESEARCH INTERESTS> | |||
| 1. Establishment of animal model of chronic glomerulonephritis
(IgA Nephropathy):HIGA mouse 2. Research for the new strategy against the drug resistant nephritic syndrome by modifying the hyperlipidemia with LDL-apheresis 3. Investigation of the immunosupportive therapy for the MPO-ANCA associated rapidly progressive glomerulonephritis 4. Establishment of the artificial Fv immunoglobulin |
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| <BIBLIOGRAPHY> | |||
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1. Ogawa N, Yano S, Yamane Y, Nishiki M, Yamaguchi T, Tanaka M, Tsukamoto T, Muso E, Sugimoto T: A case of MPO-ANCA positive IgA nephropathy successfully treated with tonsillectomy. Clin Exp Nephrol. (in print) 2. Hashimoto M, Nogaki F, Oida E, Tanaka M, Ito-Ihara T, Nomura K, Liu N, Muso E, Fukatsu A, Kita T, Ono T.: Glomerulonephritis induced by methicillin-resistant Staphylococcus aureus infection that progressed during puerperal period. Clin Exp Nephrol. 11(1):92-6, 2007 3. Tanaka M, Tsujii T, Komiya T, Iwasaki Y, Sugishita T, Yonemoto S, Tsukamoto T, Fukui S, Takasu A, Muso E: Clinicopathological Influence of Obesity in IgA Nephropathy: Comparative Study of 74 Patients Tomino Y (ed): IgA Nephropathy Today. Contrib Nephrol. Basel, Karger, 90-93, 2007 4. Hashimoto M, Nogaki F, Oida E, Tanaka M, Ito-Ihara T, Nomura K, Liu N, Muso E, Fukatsu A, Kita T, Ono T.: Glomerulonephritis induced by methicillin-resistant Staphylococcus aureus infection that progressed during puerperal period. Clin Exp Nephrol. 11(1):92-6, 2007 5. Hoshino A, Nagao T, Ito-Ihara T, Ishida-Okawara A, Uno K, Muso E, Nagi-Miura N, Ohno N, Tokunaka K, Naoe S, Hashimoto H, Yasuhara M, Yamamoto K, Suzuki K: Trafficking of QD-conjugated MPO-ANCA in Murine Systemic Vasculitis and Glomerulonephritis model mice. Microbiol.Immunol.(in print)
7. Yashiro M, Kamata T, Yamadori N, Tomita M, Muso E.: Evaluation of markers to estimate volume status in hemodialysis patients: atrial natriuretic Peptide, inferior vena cava diameter, blood volume changes and filtration coefficients of microvasculature.Ther Apher Dial. 2007 Apr;11(2):131-7.
9. Ono T, Shimosawa M, Liu N, Uemura K, Nogaki F, Mori N, Muso E, Yoshida H: Aggravation of Mesangioproliferative Glomerulonephritis through Activation of Coagulation System in a High IgA (HIGA) Strain of ddY Mice Triggered by Lipopolysaccharide. J Am Soc Nephrol 17: 310A, 2006 10. Tsukamoto T, Sugishita T, Iwasaki Y, Tsujii T, Fukuuchi F, Komiya T, Muso E: N-Cadherin Expression Decrease in Hyperplastic Parathyroid Glands in Chronic Dialysis Patients. J Am Soc Nephrol 17: 698A, 2006 11. Ito-Ihara T, Ono T, Nogaki F, Suyama K, Tanaka M, YonemotoS, Fukatsu A, KitaT, Suzuki K, Muso E: Clinical Efficacy of Intravenous Immunoglobulin for Patients with MPO-ANCA-Associated Rapidly Progressive Glomerulonephritis. Nephron Clin Pract. 102(1):c35-c42, 2006. 12. Shimosawa M, Liu N, Uemura K, Muso E, Yoshida H, Ono T: Exacerbating mechanisms mediated by LPS-induced activation of coagulation system in IgA nephropathy model mouse HIGA. Nephrology 11 A58, 2006. 13. Tanaka M, Tsujii T, Tahara S, Yonemoto S, Tsukamoto T, Sugishita T, Fukui S, Takasu A, Muso E: Clinicopathological influence of excess body weight in IgA nephropathy: comparative study of 68 patients. Nephrology 10 A435-6, 2005. 14. NogakiF, Oida E, Kamata T. Kobayashi I, Nomura K, Suyama K,Tahara S, Fukatsu A, Ono T, Miyawaki S, Serikawa T, Kita T, Muso E: Chromosomal Mapping of Hyperserum IgA and Glomerular IgA Deposition in a High IgA (HIGA) Strain of DdY Mice. Kidney Int 68 2517-2525, 2005. 15. Muso E , Komiya T, Iwasaki Y, Tahara S, Sugishita T, Tsujii T, Tsukamoto T: Thioredoxin (TRX) possibility plays a key role in prevention of active crescentic glomerular lesion induced by IL-12, brought about by Angiotensin Receptor Blocker (ARB) in high IgA strain (HIGA) of ddY mice. Abstract of The 3rd meeting of International Redox Network (2005.11.9-11 (Kyoto)) 66, 2005. 16. Tsukamoto T, Sugishita T, Iwasaki Y, Tahara S, Tsujii T, Komiya T, Muso E: Possible Involvement of Src Kinase through Proteasome in Controlling Cell-Cell Adhesion after Ischemic Renal Tubular Damage. J Am Soc Nephrol 16: 394A, 2005 17. Komiya T, Iwasaki Y, AsadavH, Tahara S, Sugishita T, Tsujii T, Tsukamoto T, Muso E: Angiotensin Receptor Blocker (ARB) Prevents the Induction of Active Crescentic Glomerular Lesion by IL-12 Possibly through Suppression of Oxidative Stress with TNF-a Expression in High IgA Strain (HIGA) of ddY Mice. J Am Soc Nephrol 16: 417A, 2005 18. Kasuno K, Akaike A, Sugimoto H, Muso E, Yodoi J, Ono T: Serofedic Acid, a Novel Diterpenoid from Fetal Calf Serum, Prevents Renal Ischemia-Reperfusion Injury in Mice. J Am Soc Nephrol 16: 626A, 2005 19. Muso E, Yukawa S, Nishizawa Y, Saito T, Yorioka N, Mune M, HiranoT, Hattori M, Kimura K: Survey of 94 cases of refractory nephrotic syndrome (NS) showing rapid remission by low-density lipoprotein apheresis (LDL-A). Nephrology 10(Suppl): A37, 2005 20. Ito-Ihara T, Uno K, Ono T, Fukatsu A, KitaT, Suzuki K, Muso E: Circulating myeloperoxidase and cytokine profiles in myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis. Nephrology 10(Suppl): A53, 2005 21. Muso E, Ito-Ihara T, Ono T, Imai E, Yamagata K, Akamatsu A, Suzuki K:Establishment of the Evidence of BeneficialEffect of Intravenous Immunoglobulin 8IVIg) Therapy on MPO-ANCA Related Polyangiitis Combining Rapidly Progressive Glomerulonephritis (RPGN) in Japan. Kidney & Blood Pressure Research 28 (3):180, 2005 22. Ito-Ihara T, Uno K, Hoshino A, Yamamoto K, Komiya T, Ishida-Okawara A, Fukatsu A, Kita T, Suzuki K, Muso E: Sensitive Detection of Myeloperoxidase Expression on Neutrophil of Patients with Myeloperoxidase-antinuetrophil Cytoplasmic Antibody-associated Glomerulonephritis. Kidney & Blood Pressure Research 28 (3):183, 2005 23. Hoshino A, Nagao T, Murayama K, Ishida-Okawara A, Ito-Ihara T, Uno K, Muso E, Nagai-Miura N, Ohno N, Naoe S, Tokunaka K, Yasuhara M, Yamamoto K, Suzuki K: Contribution of Myeloperoxidase (MPO) on Surface of Neutrophils to Glomerulonephritis Using Nanocrystal Quantum Dots-labeled MPO Antibody. Kidney & Blood Pressure Research 28 (3):183, 2005 24. Kobayashi S, Tamura N, Ihara T, Muso E, Suzuki K, Yoshida M, Nakabayashi K, Tsuchiya N, Kurosawa M, Inaba Y, Fujimoto S, Nunoi H, Hashimoto H: Prevalence of Microscopic Polyangiitis/ Wegener’s Granulomatosis and the Ratio of MPO, PR-3-ANCA in Patients with ANCA-assosciated Vasculitis in Japan. Kidney & Blood Pressure Research 28 (3):190, 2005 25. Yashiro M, Watanabe H, Tomita M, Yamadori N, Muso E: Relationship between filtration coefficients of microvasculature and levels of atrial natriuretic peptide or echocardiographic measurements. Blood Purif. 23(6):431-9, 2005.
27. Tanaka M, Oida E, Nomura K, Nogaki F, Fukatsu A, Uemura K, Yashiro M, Kimura T, Muso E, Ono T:The Na+-excreting Efficacy of Indapamide in Combination with Furosemide in Massive Edema. Clin Exp Nephrol 9(2):122-6, 2005 28. Ono T, Liu N, Makino T, Nogaki F, Muso E, Honda G, Kita T: Suppressive Mechanisms of Sairei-to on Mesangial Matrix Expansion in Rat Mesangioproliferative Glomerulonephritis. Nephron Exp Nephrol. 100(3):e132-42, 2005. 29. Muso E, Ito-Ihara T, Ono T, Imai E, Yamagata K, Akamatsu A, Suzuki K: Intravenous immunoglobulin (IVIg) therapy in MPO-ANCA relatedpolyangiitis with rapidly progressive glomerulonephritis in Japan. Jpn J Infetc Dis 57(5):S17-18, 2004 30. Suzuki K, Muso E, Nauseef WM: Contribusion of peroxidases in host-defense, diseases and cellular functions. Jpn J Inect Dis 57(5):S1-2, 2004 31. Liu N, Makino T, Honda G, Muso E, Kita T, Ono T: Suppressive effects of Sairei-to on mesangial proliferation in a rat model of glomerulonephritis. Clin Exp Nephrol 8(3):216-222, 2004 32. Liu N, Makino T, Nogaki F, Kusano H, Suyama K, Muso E, Honda G, Kita T, Ono T: Coagulation in the mesangial area promotes extracellular matrix accumulation through factor V expression in mesangioproliferative glomerulonephritis in rats. Am J Physiol Renal Physiol 287(4):F612-620, 2004 33. Ono T, Liu N, Makino T, Nogaki F, Nomura K, Muso E, Shimizu F, Honda G, Kita T: Role of Mesangial Factor V Expression in the Crescent Formation in Rat Experimental Mesangioproliferative Glomerulonephritis. J Pathol 204(2):229-238, 2004 34. Oida E, Nogaki F, Kobayashi I, Kamata K, Ono T, Miyawaki S, Serikawa T, Yoshida Y, Kita T, Muso E: Quantitative trait loci (QTL) analysis reveals a close linkage between the hinge region and trimeric IgA dominancy in a high IgA strain (HIGA) of ddY mice. Eur J Immunol 34(8):2200-2208, 2004 35. Yashiro M, Watanabe H, Muso E: Simulation of Postdialysis Urea Rebound Using Regional Flow Model. Clin Exp Nephorol 8(2):139-145, 2004 36. Hayase T, Yamamoto Y, Yamamoto K, Muso E, Shiota K: Microarray profile analysis of toxic cocaine-induced alterations in the expression of mouse brain gene sequences: a possible 'protective' effect of buprenorphine. J Appl Toxicol 24(1):15-20, 2004 37. Shibasaki T, Koyama A, Hishida A, Muso E, Yamabe H, Shiiki H, Makino H, Sato H, Ishikawa I, Maeda K, Tomita K, Arakawa M, Ishida M, Sato M, Kashihara N, Yorioka N, Koike T, Saito T, Harada T, Nitarai T, Sugisaki T, Nagasawa T, Tomino Y, Nojima Y, Kobayashi Y, Sakai O: A randomized Open-Label Comparative Study Of Conventional Therapy versus Mozoribine Only Therapy in Patients with Steroid-Resistant Nephrotic Syndrome (Postmarketing survbey) Clin Exp Nephrol 8(2):117-126, 2004 38. Ishida-Okawara A, Ito-Ihara T, Muso E, Ono T, Saiga K, Nemoto K, Suzuki K: Neutrophil contribution to the crescentic glomerulonephrritis in SCG/Kj mice. Nephrol Dial Transplant 19(7):1708-1715, 2004. 39. Nogaki F. Oida E, Kobayashi I, Nomura K, Suyama K, Ono T, Miyawaki S, Yoshida H, Kita T, Muso E: Genetic locus of high serum IgA: Quantitative trait loci (QTL) analysis in high serum IgA ddY (HIGA) mice. Nephrology 8:A116, 2003 40. Hayase T, Yamamoto Y, Yamamoto K, Muso E, Shiota K: Stressor-like effects of cocaine on heat shock protein and stress-activated protein kinase expression in the rat hippocampus: interaction with ethanol and anti-toxicity drugs. Leg Med (Tokyo). Mar;5 Suppl 1:S87-S89, 2003 41. Hanta T, Ono T, Watanabe H, Takeda T, Muso E, Kita T: Glomerulonephritis Induced by Methicillin-Sensitive Staphylococcus aureus Infection. Clin Exp Nephrol7(3):247-249, 2003 42. Hayase T, Yamamoto Y, Yamamoto K, Muso E, Shiota K, Hayashi T: Similar effects of cocaine and immobilization stress on the levels of heat-shock proteins and stress-activated protein kinases in the rat hippocampus, and on swimming behaviors: the contribution of dopamine and benzodiazepine receptors. Behav Pharmaco 14(7):551-562, 2003 43. Kasuno K, Nakamura H, Ono T, Muso E, Yodoi J: Protective roles of thioredoxin, a redox-regulating protein, in renal ischemia-reperfusion injury. Kidney Int 64(4):1273-1282, 2003 44. Kasuno K, Ono T, Matsumori M, Nogaki F, Kusano H, Watanabe H, Yodoi J, Muso E: Hepatitis C Virus-Associated Tubulointerstitial Injury. Am J Kid Dis 41(4):767-775, 2003 45. Hamada K, Nagai S, Ono T, Muso E, Nagao T, Shigematsu M, Izumi T, Mishima M: Sarcoidosis complicated with IgA nephropathy. Sarcoidosis Vasc Diffuse Lung Dis 20(1):69-73, 2003 46. Makino T, Ono T, Matsuyama K, Nogaki F, Miyawaki S, Honda G, Muso E: Suppressive effects of Perilla frutescens on IgA nephropathy in HIGA mice. Nephrol Dial Transplant 18(3):484-490, 2003 47. Ito-Ihara T, Nogaki F, Ono T, Suzuki K, Muso E: Intravenous immunoglobulin (IVIG) treatment of MPO-ANCA-related microscopic polyangiitis. Cleveland Clinic Journal of Medicine, 188; 69 (5) suppl. 2, 2002 48. Yashiro M, Hamada Y, Matsushima H, Muso E: Estimation of filtration coefficients and circulating plasma volume by continuously monitoring hematocrit during hemodialysis. Bood Purification 20(6):569-576, 2002 49. Kobayashi I, Nogaki F, Kusano H, Ono T, Miyawaki S, Yoshida H, Muso E: Interleukin-12 alters the physicochemical characteristics of serum and glomerular IgA and modifies glycosylation in a ddY mouse strain having high IgA levels. Nephrol Dial Transplant 17(12): 2108-2117, 2002 50. Ono T, Liu N, Kusano H, Nogaki F, Makino T, Muso E, Sasayama S: Broad Antiproliferative Effects of Benidipine on Cultured Human Mesangial Cells in Cell Cycle Phases. Am J Nephrol 22(5-6):581-586, 2002 51. Makino T, Ono T, Liu N, Muso E, Honda G: Suppressive effect of Rosmarinic Acid on Mesangial Prroliferative Glomerulonephritis in Rats. Nephron 92(4):898-904, 2002 52. Makino T, Ono T, Muso E, Honda G: Effect of Perilla frutescens on nitric oxide production and DNA synthesis in cultured murine vascular smooth muscle cells. Phytother Res 16 (Suppl 1):19-23, 2002 53. Kusano H, Muso E, Ono T, Nogaki F, Nomura K. Takeda T, Miyawaki S, Matsumori A, Yoshida H, Sasayama S: Heminephrectomy causes the progression of glomerulonsclerosis and apoptosis in high IgA strain ddY mice. Nephron 92(2):389-398, 2002 54. Matsushima H, Yoshida H, Machiguchi T, Muso E, Tamura T, Sasayama S: Urinary albumin and TGF β1 levels as renal damage indices in patients with congestive heart failure. Clin Exp Nephrol (in print) 55. Shirakawa K, Muso E, Nogaki F, Maeda M, Kawamura T, Ono T, Yoshimoto M, Uno K, Kishida T, Sasayama S: Correlation between the severity of clinicopathological parameters and whole blood interferon alpha production acapacity in active phase IgA nephropathy patients. Nephron 90(1):24-30, 2002 56. Kusano H, Miyawaki S, Yoshida H, Ono T, Muso E, Sasayama S: Heminephrectomy causes the progression of glomerulosclerosis and apoptosis in high IgA strain of ddY(HIGA)mice. Nephrology 6(suppl):A4, 2002 57. Liu N, Ono T, Kawamura T, Kobayashi I, Muso E, Sasayama S: Preeclamptic nephropathy associated with membranous nephropathy. Clin Exp Nephrol 5:268-271, 2001 58. Makino T, Ito M, Kiuchiu F, Ono T, Muso E, Honda G: Inhibitory effect of decoction of Perilla frutescens on cultured murine mesangial cell proliferation and quantitative analysis of its active constituents. Planta Med 67(1):24-28, 2001 59. Makino T, Nakamura T, Ono T, Muso E, Honda G: Suppressive effects of Perilla frutescens on mesangioproliferative glomerulonephritis in rats. Biol Pharm Bul 24(2):172-175, 2001 60. Katsuma S, Shiojima, Hirasawa A, Suzuki Y, Takagaki K, Murai M, Kaminishi Y, Hada Y, Kova M, Muso E, Miyawaki S, Ohgi T, Yano J, Tsujimoto G: Genomic analysis of a mouse model of immunoglobulin A nephropathy reveals an enhanced PDGF-EDG5 cascade. The Pharmacogenetics Journal 1:211-217, 2001 61. Ono T, Liu N, Kasuno K, Kusano H, Nogaki F, Kamata T, Suyama K, Muso E, Sasayama S: Coagulation process proceeds on cultured human mesangial cells via expression of factor V. Kidney Int 60(3):1009-1017, 2001 62. Tanaka M, Ono T, Takeda T, Watanabe H, Muso E, Sasayama S: A case of Candida peritonitis followed by dekiastinitis after esophageal perforation in a PD patient(letter). Periton Dial Int 21(3):316, 2001 63. Nogaki F, Muso E, Yashiro M, Kasuno K, Kamata T, Ono T, Sasayama S: Direct effects of simbastatin on proliferation and matrix accumulation in cultured murine mesangial cells. Clin Exp Nephrol 5:85-89, 2001 64. Muso E, Mune M, Fujii Y, Imai E, Ueda N, Hatta K, Imada A, Takemura T, Miki S, Kuwahara T, Takamitsu Y, Tsubakihara Y, K-FLAT Study Group: Significantly rapid relief from steroid resistant nephrotic syndrome by LDL-apheresis compared with steroid monotherapy. Nephron 89(4):408-415, 2001 65. Yashiro M., Muso E., Kamata T., Oyama A., Sasayama S. Yoshida H.: Altered cultureed mesangial cell phenotypes from RF/J mice : A spontaneous immune comples mediated glomerulonephritis with progressive glomerulosclerosis. Experimental Nephrol. Dec;89(4):408-15、2001 66. Oyama A., Muso E., Ono T., Matsushima H., Yasihro M., Suyama K., Kamata T., Nogaki F., Kobayashi I., Miyamaki S., Yoshida H., Sasayama S.: Up-regulated TGF-b mRNA expression in splenic T cells of high IgA-prone (HIGA) mice, a murine model of IgA nephropathy with glomerulosclerosis. Nephron . Aug;88(4):368-75 2001 67. Muso E.: Epidemiology of renal diseases and high blood pressure among university students in Japan. Proceeding of the 5th Franco-Japanese symposium of nephrology 12-20,2000 68. Suyama K., Muso E., Yashiro M., Sasayama S.: Significant suppressive effect of low dose temocapril(TEM), and ACE inhibitor with biliary excretion, on FGS lesions in hypertensive rats. Nephron . 86 491-498. 2000 69. Makino T., Ono T., Muso E., Yoshida H., Honda G., Sasayama S.: Inhibitory effects of rosmarinic acid on the proliferation of cultured murine mesangial cells.Nephrol Dial Transplant.15:1140-1145.2000 70. Nogaki F., Muso E., Kobayashi I., Kusano H., Shirakawa K., Kamata T., Oyama A., Ono T., Miyawaki S., Yoshida H., Sasayama S.: Interleukin 12 induces crescentic glimerular lesions in a high IgA strain of ddY mice.. Nephrol Dial Transplant 15.1146-1154.2000 71. Liu M., Ono T., Suyama K., Nogaki F., Shirakawa K., Maeda M., Kawamura T., Kamata T., Oyama A, Muso E., Sasayama S.:Mesangial Factor V expression colocalized with fibrin deposition in IgA nephropathy Kidney Int .58:598-606.2000 72. Kobayashi I,., Muso E., Kusano H., Nogaki F., Miyawaki S., Yoshida H., Sasayama S.: The abnormal glycosylation of serum and glomerular IgA in a high IgA strain of ddY mice. Nephrology . 5 (supple) A46. 2000 73. Yashiro M., Muso E., Itoh T., Oyama A., Hashimoto k., Kawamura T., Ono T., Sasayama S.: Significantly high regional morbidity of MPO-ANCA related angitis and/or nephritis with respiratory tract involvement after the great earthquake of Kobe in 1995. Am J. Kid Dis.. 35(5) 889-895. 2000. 74. Kamata T., Nogaki F., Fagarasan S., Kobayashi I., Miyawaki S., Ikuta K., Muso E., Yoshida H., Sasayama S., Honjo T.: High Frequency of surface IgA positive plasma cells in the intestinal lamina propria of HIGA mice, a murine model of IgA nephropathy with hyper-serum IgA. J. Immunol:.165.1387-1394.2000 75. Watanabe H., Ono T. Muso E., Matsumori A., Sasayama S.: Tubulointerstitial nephritis, cardiomyopathy, and hepatitis in hepatitis C virus infection" for our consideration.. Am J Med (letter). 109(2). 176-177, 2000 76. Takeda K., Mitsunami K., Muso E., Kinoshita M., Sasayama S., Nakagawa M.: Efficaty of celiprolol in treatment of hypertension in the elderly. Current therapeutic research 61 (1)49-60,2000 77. .Inagaki K., Kihara Y., Hayashida W., Izumi T., Yoneda T., Takeuchi Y., Iwanaga Y., Suyama K., Muso E., Sasayama S.: Anti-Ischemic Effect of a novel cardioprotective agent JTV519 is mediated through specific activation of d-Isoform of protein kinase C in rat ventricular myocarrdium: Circulation. 101(7), 797-804. 2000 78. Wakasugi H, Kaneda N, Hashida T, Futami T, Ishizu M, Ono T, Nohara R, Muso E, Sasayama S and Inui K: Thrombocytopenia induced by niceritrol used for amelioration of hyperphosphatemia in a hemodialysis patient. Nephron(letter)86:97-98.2000 79. Imasawa T, Nagasawa R., Utsunomiya Y., Kawamura T., Zhong Yu., Makita N., Muso E., Miyawaki S., Sakai O., Maruyama N., Ohno T. : Bone marrow transplantation as a promising treatment for immunoglobulin A nephropathy: The role of a stem cell disorder in the pathogenesis . Kidney Int 56:1809-1817.1999 80. Kawamura T, Muso E, Kamata T, Suyama K, Oyama A, Ono T, Yoshida H, Miyawaki S and Sasayama S: Ultrastructural localization of dominantly increased fibronectin in markedly thickend glomerular basement membrane in selectively mated murine high IgA strain (HIGA mice). Nephron 83:145-153,1999 81. Muso E, Mune M, Fujii Y, Imai E, Ueda N, Hatta K, Imada A, Miki S, Kuwahara T, Takamitsu Y, Takemura T, Tsubakihara Y, for the Kansai -FGS-Apheresis Treatment (K-FLAT) Study Group: Low density lipoprotein apheresis therapy for steroid-resistant nephrotic syndrome. Kidney Int. 56, suppl.71: S122-S125, 1999. 82. Muso E, Shirakawa K, Nogaki F, Uno K and Sasayama S: The effect of Th1/Th2 dominance on the clinicopathological feature of human and murine model of IgA nephropathy. Proceeding of 4eme Symposium Franco-Japonais de Nephrologie conference pp21-25, 1999. 83. Nogaki F, Kobayashi I, Kusano H, Shirakawa K, kamata T, Ono T, Muso E, Miyawaki S, Yoshida H, Sasayama S: Relationship between the immunological background and the induction of inflammatory renal lesions by IL-12 in a high IgA strain of ddY mice. Nephrology (supple) 5:A6-A7, 1999. 84. Makino T, Ono T, Muso E, Honda G and Sasayama S: Suppresive effects of Perilla frutescens on spontaneous IgA nephropathy in ddY mice. Nephron 83:40-46,1999. 85. Sakurai M, Muso E, Matsushima H, Ono T, Sasayama S: Rapid normalization of interleukin-8 production after low-density lipoprotein apheresis in steroid-resistant nephrotic syndrome. Kidney Int. 56, suppl.71: S210-S212, 1999. 86. Nogaki F. Muso E,Yashiro M, Kasuno K, Kamata T, Ono T, Sasayama S: Direct Inhibitory Effects of Simvastatin on Matrix accumulation in cultured murine mesangial cells: Kidney Int. 56, suppl.71: S198-S201, 1999. 87. Makino T, Ono T, Ito M, Muso E, Honda G: Effect of Perilla frutescens Extract on nitric oxide production by cultured murine mesangial cells. Biol. Pharm Bull 22(5): 476-480, 1999. 88. Machiguchi T, Yoshida H, Yonemoto S, Minakata T. Nomura K. Muso E, Tamura T, Sasayama S: Does circulating erythropoietin reflect progression of IgA npheorpathy? Comparison with urinary N-acetyl-b-D-glucosaminidase. Nephrol. Dial. Transplant. 14(3):635-640, 1999. 89. Kamata T, Muso E, Yashiro M, Kawamura T, Oyama A, Matsushima H, Takeuchi E, Yoshida H and Sasayama S: Up-regulation glomerular extracellurar matrix and transforming growth factor-β expression in RF/J mice. Kidney Int 55:864-876, 1999. 90. Yashiro M, Muso E, Itoh T, Oyama A, Ono T and Sasayama S: Significantly High Incidence and High Morbidity of Acute Renal Failure with Respiratory Tract Involvement of p-ANCA-Related Angitis Revealed in Kobe City and the Environs after the Kobe Earthquake in 1995. Clinical Nephrology (Letter) 51(3):190-191, 1999. 91. Ono T, Yashiro M, Oyama A, Yoshida H, Muso E and Sasayama S: Inhibitory effects of the herbal medicine Saiboku-to on the proliferation of cultured murine mesangial cells. Nephrology 4: 367-372, 1998. 92. Nogaki F, Muso E, Kasuno K, Fukushima H, Shirakawa K, Kamata T, Kawamura T, Sakurai M, Ono T, Miyawaki S, Yoshida H and Sasayama S: Age-associated relative shift to Th2 predominance and the effects of IL-12 administration in high IgA strain of ddY mice. Nephrology 4(supple):A4, 1998. 93. Ono T, Muso E, Honda G, Kuwahara T: Association of valvular heart disease with Chinese-herb nephropathy. Lancet (letter) 351(9107):991-992, 1998. 94. Makino T, Honda G, Ono T, Muso E, Sasayama S: Inhibiltory effect of Perilla Frutescens on cultured murine mesangial cell proferation. Planta Medica 64(6):541-545, 1998. 95. Yoshida H, Yashiro M, Liang P, Muso E, Takeuchi E, Shimada T, Sekita K, Ono T, Kanatsu K, Sugiyama T, Kawai C, Sasayama S: Mesangiolytic glomerulopathy with glomerular enlargement in congestive heart failure. Kidney Int 53:880-891, 1998 96. Ozaki K, Takada N, Tsujimoto K, Tsuji N, Kawamura T, Muso E, Ohta M, Itoh N: Localization of insulin receptor-related receptor in the rat kidney. Kidney Int 52: 694-698,1997. 97. Haku E, Muso E, Nogaki F, Sakurai M, Kawamura T, Kamata T, suyama K, Oyama A, Ono T, Sasayama S, Nishimoto E, Yoshimoto M, Uno K, Kishida T: Whole-Blood interferon-producing capacity in IgA nephropathy patients. Nephrology 3 (supple):A14,1997 98. Kasuno K, Ono T, Kamata T, Kawamura T, Suyama K, Oyama A, Matsushima H, Kuwahara T, Muso E, Sasayama S: IgA nephropathy associated with polycythemia vera: accelerated course. Nephrol Dial Transplant 12: 212-215, 1997. 99. Miyawaki S, Muso E, Takeuchi E, Matsushima H, Shibata Y, Sasayama S, Yoshida H: Selective breeding for high serum IgA levels from noninbred ddY mice: Isolation of a strain with an early onset of glomerular IgA deposition. Nephron 76: 201-207, 1997. 100. Muso E, Yoshida H, Takeuchi E, Yashiro M, Matsushima H, Oyama A, Suyama K, Kawamura T, Kamata T, Miyawaki S, Izui S and Sasayama S: Enhanced production of glomerular extracellular matrix in a new mouse strain of high serum IgA ddY mice. Kidney Int 50:1946-1957, 1996. 101. Ono T, Muso E, Sasayama S: Intraglomerular deposition of intact cross linked fibrin in IgA nephropathy and Henoch-Sch嗜lein purpura nephritis. Nephron 74: 522-528, 1996. 102. Ono T, Muso E, Sasayama S: Detection of the intact cross linked fibrin in renal biopsy specimens by the antibody DD3B6/22 and plasmin treatment. Fibrinolysis 10, Suppl. 4: 1-26, 1996. 103. Ono T, Nagai H, Kanatsu K, Kudoh T, Onoe C, Utsunomiya K, Hara A, Matsuoka S, Matsushima H, Muso E, Sasayama S: Relationship between obsoruction of arteriovenous fistula and plasma level of endothelin-1 in long-term haemodialysis patients. Nephrology 2, 253-256, 1996. 104. Ono T, Sakurai M, Kawamura T, Kamata T, Suyama K, Oyama A, Doi T, Onoe C, Nagai H, Muso E, Sasayama S: Efficacy of amlodipine in hypertensive dialysis patients to deviation of blood pressure during sialysis. Theapeutic Res 17: 4951-4959, 1996. 105. Koide M, Furukawa F, Wakita H, Tokura Y, Muso E, Takigawa M: Soluble form of vascular cell adhesion molecule-1 in systemic lupus erythematosus and discoid lupus erythematosus. J Dematol Sci 12: 73-75, 1996. 106. Muso E, Yashiro M, Yoshida H: Phenotypic variation of mesangial cells from a murine modelof spontaneous sclerosing glomerulonephritis, RF/J mice. Proceeding of 2eme Symposium Franco-Japonais de Nephrologie donference pp115-118, 1995. 107. Kawamura T, Kamata T, Suyama K, Matsushima H, Oyama A, Ono T, Muso E, Sasayama S: Two cases with MPO-ANCA, PR3-ANCA, anti-nuclear antibody and anti-GBM antibody positive rapidly progressive glomerulonephritis. Clin Exp Immunol, 101 (suppl. 1), 60, 1995. 108. Yashiro M, Muso E, Shio H, Sasayama S: Amelioration of hypercholesterolaemia by HMG-CoA reductase inhibitor (Pravastatin) improved platelet hyperaggregability in nephrotic patients. Nephrology Dial Transplant 9, 1842-1843, 1994. 109. Yashiro M, Muso E, Matsushima M, Nagura R, Sawanishi K, Sasayama S: Two-compartment model of cholesterol kinetics for establishment of trearment strategy of LDL apheresis in nephtoric hypercholesterolemia. Blood Purif 12, 317-326, 1994. 110. Muso E, Yashiro M, Ito Y, Yoshida H, Sasayama S: Correlations of C1q- and C3d-bearing circulating immune complexes with immunopathological disease activity in lupus nephritis patients. Jpn J Nephrol, 36, 345-354, 1994. 111. Yoshida H, Kanatsu K, Muso E, Kuwahara T, Sekita K, Ono T, Konishi N, Kanda C, Minakata T, Morimoto K, Takemura S, Umeda Y, Suzuki T, Shu Y, Takashima K, Tamura T: Effects of an Anti-platelet drug (dilazep) in IgA nephropathy: comparison of clinical effects with renal biopsy findings. Jpn J Nephrol, 36, 339-344, 1994. 112. Muso E, Yashiro M, Matsushima M, Yoshida H, Sawanishi K, Sasayama S: Does LDL-apheresis in steroid-resistant nephrotic syndrome affect prognosis? Nephrol Dial Transplant 9: 257-264, 1994. 113. Ono T, Kanatsu K, Ueda S, Matsuo T, Kuwahara T, Onoe C, Nagai H, Muso E, Sasayama S: Detection of the antigenicity of the D-dimer of cross linked fibrin in the glomerulus by plasmin treatment. Kidney Int, 46, 260-265, 1994. 114. Oota E, Muso E, Ogawa K, Matsunaga M: Effect of antihypertensive agents on experimental malignant naphrotic syndrome induced in spontaneously hypertensive rats. Nifedipine quarter century symposium Tokyo '93, 65-74, 1994. 115. Muso E, Tamura I, Yashiro M, Asaka Y, Kataoka Y, Nagai H, Takahashi T: Waldenstr嗄's macroglobulinemia associated with amyloidosis and membranous nephropathy. Jpn J Nephrol 35, 1265-1269, 1993. 116. Muso E, Fujiwara H, Yoshida H, Hosokawa R, Yashiro M, Hongo Y, Matsumiya T, Yamabe H, Kikuta H, Hironaka T, Hirai K, Kawai C: Epstein-Barr virus genome-positive tubulo-interstitial nephritis associated with Kawasaki disease-like coronary aneurysms. Clin Nephrol 40, 7-15, 1993. 117. Nagayama Y, Imura H, Muso E: Decrease in renal function folloing decreased fibrinogen and raised fibrin degradation products in lupus nephritis with nephrotic syndrome. Scand J Urol Nephrol 26: 387-391, 1992. 118. Ono T, Kanatsu K, Doi T, Sekita K, Onoe C, Nagai H, Muso E, Yoshida H, Tamura T, Kawai C: Relationship of intraglomerular coagulation and platelet aggregation to glomerular sclerosis. Nephron 58, 429-436, 1991. 119. Muso E, Yoshida H, Takeuchi E, Shimada T, Yashiro M, Sugiyama T, Kawai C: Pathogenic role of polyclonal and multimeric IgA in a murine model of mesangial proliferative glomerulonephritis with IgA deposition. Clin Exp Immunol 84, 459-465, 1991. 120. Yashiro M, Muso E, Yoshida H, Shimada T, Matsushima M, Sawanishi K, Sugiyama T, Kawai C: Different appearance and pathogenic roles of serum IgA against autologous IgG Fc and Fab in patients with IgA nephropathy. Jpn J Nephrol 33, 497-506, 1991. 121. Ikehara S, Yasumizu R, Inaba M, Izui S, Hayakawa K, Sekita K, Toki J, Sigiura K, Iwai H, Nakamura T, Muso E, Hamashima Y, Good RA: Long-term observations of autoimmune-prone mice treated for autoimmune disease by allogeneic bone marrow transplantation. Proc Natl Acad Sci USA 86, 3306-3310, 1989. 122. Ono T, Kanatsu K, Doi T, Sekita K, Onoe C, Nagai H, Muso E, Yoshida H, Tamura T, Kawai C: Ultrastructural distribution of von Willebrand factor in human glomerular diseases. Nephron 53, 311-316, 1989. 123. Ono T, Kanatsu K, Doi T, Sekita K, Nagai H, Muso E, Yoshida H, Tamura T, Kawai C: Immunoelectron microscopic localization of fibrin-related antigen in human glomerular diseases. Nephron 52, 238-243, 1989. 124. Yoshioka H, Yoshida H, Doi T, Muso E, Ohshio G, Higuchi K, Inada M, Miyoke T, Kita T, Hamashima Y, Takeda T: Autoimmune abnormalities in a murine model of accelelated senescence. Clin Exp Immunol 785, 129-135, 1989. 125. Takeuchi E, Doi T, Shimada T, Muso E, Maruyama N, Yoshida H: Retroviral gp 70 antigen in spontaneous mesangial glomerulonephritis of ddy mice. Kidney Int 35, 638-646, 1989. 126. Muso E, Pen T, Kudo T, Yoshida H: Specific binding to methylated polynucleotides in monoclonal anti-poly (dT) antibodies from autoimmune mice. Clin Immunol Immunopathol 50, 298-306, 1989. 127. Tamura T, Konishi N, Yoshida H, Kuwahara T, Muso E, Kawai C: Pathogenesis of hypertention in IgA nephropathy. Poi Arch Med Wewn 80, 221-227, 1988. 128. Nagayama Y, Namura Y, Tamura T, Muso E: Beneficial effect of prostaglandin E1 in three cases of lupus nephritis with nephrotic syndrome. Annals of Allergy 61, 289-295, 1988. 129. Ikehara S, Nakamura T, Sekita K, Muso E, Yasumizu R, Ohtsuki H, Hamashima Y, Good RA : Treatment of systemic and organ-specific autoimmune disease in mice by allogenic bone marrou transplantation. Prog-Clin-Biol-Res 229, 131-46, 1987. 130. Yoshida M, Yoshida H, Muso E, Tamura T, Shimada T, Kawai C, Hamashima Y: Clonotype comparison of IgG anti-DNA antibodies of healthy subjects and systemic lupus erythematosus patients: studies on heterogeneity and avidity. Immunol Let 15, 139-144, 1987. 131. Yoshida M, Yoshida H, Muso E, Kawai C, Hamashima Y: Avidity of anti-DNA antibodies and its clinical significance in patients with SLE. Jpn Arch Int Med 34, 89-96, 1987. 132. Muso E, Yoshida H, Sekita K, Konishi N, Tamura T, Kanatsu K, Kawai C, Hamashima Y: Immunopathological correlations of circulating immune complexes and anti-DNA antibodies to glomerular lesions in systemic lupus erythematosus. Jpn J Nephrol 29, 501-509, 1987. 133. Muso E, Jacob L: A polyspecific monoclonal anti-DNA autoantibody also binds to cell-surface protein (s). Clin Immune Immunopathol 42, 370-374, 1987. 134. Nagata N, Muso E, Sekita K, Hamashima Y: STS-reactive IgG antibodies and anti-dsDNA antibodies in the sera from patients with systemic lupus erythematosus. IRCS Med Sci 13, 1120-1121, 1985. 135. Ikehara S, Good RA, Nakamura T, Sekita K, Inoue S, Oo MM, Muso E, Ida T, Kuzuya H, Imura H, Hamashima Y: Prevention of type I diabetes in nonobese diabetic mice by allogeneic bone marrow transplantation. Proc Natl Acad Sci USA 82, 7743-7747, 1985. 136. Muso E, Yoshida H, Sekita K, Tamura T, Kawai C, Hamashima Y: Low serum levels of IgG- and IgM-rheumatoid factors in patients with idiopathic membranous nephropathy. Jpn J Nephrol 27, 279-285, 1985. 137. Ikehara S, Good RA, Nakamura T, Sekita K, Inoue S, Oo MM, Muso E, Ogawa K, Hamashima Y: Rationale for bone marrow transplantation in the treatment of autoimmune diseases. Proc Natl Acad Sci USA 82, 2483-2487, 1985. 138. Sekita K, Doi T, Muso E, Yoshida H, Kanatsu K, Hamashima Y: Correlation of C3d fixing circulating immune complexes with disease activity and clinical parameters in patients with systemic lupus erythematosus. Clin Exp Immunol 55, 487-494, 1984. 139. Muso E, Sekita K, Doi T, Kuwahara T, Yoshida H, Tamura T, Kawai C, Hamashima Y: Immunopathological correlation between mesangial C3d-deposition and C3d-fixing circulating immune complexes in lupus nephritis. Clin Immunol Immunopathol 32, 351-358, 1984. 140. Furukawa F, Sekita K, Muso E, Imamura S, Hamashima Y: Effect of single-stranded DNA on circulating immune complexes in SLE sera detected by C1q-solid-phase assay. Dermatol Res 276, 1-4, 1984. 141. Yoshida H, Muso E, Inoue S, Fukukawa F, Sekita K, Kawai C, Hamashima Y: Evaluation of circulating immune complexes in lupus nephritis by solid phase C1q and conglutinin binding assays. Jpn J Nephrol 26, 293-300, 1984. 142. Tomita K, Muso E, Tamura T, Kawai C: The effect of hypofinogenemia with batoroxobin on rat Masugi nephritis. Jpn J Nephrol 46, 577-582, 1982. 143. Tamura T, Tomita K, Muso E, Kawai C: Electron microscopic observation
of the glomerular lesions in various renal diseases. J Clin Electron Microscopy
14, 5-6, 1981. |
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